Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges
The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed the urgent need for the development of a syste...
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| Materyal Türü: | Makale |
| Dil: | English |
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MDPI AG
2023-01-01
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| Seri Bilgileri: | Vaccines |
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| Online Erişim: | https://www.mdpi.com/2076-393X/11/2/268 |
| _version_ | 1827755268788715520 |
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| author | Sumira Malik Shristi Kishore Sagnik Nag Archna Dhasmana Subham Preetam Oishi Mitra Darwin A. León-Figueroa Aroop Mohanty Vijay Kumar Chattu Marjan Assefi Bijaya K. Padhi Ranjit Sah |
| author_facet | Sumira Malik Shristi Kishore Sagnik Nag Archna Dhasmana Subham Preetam Oishi Mitra Darwin A. León-Figueroa Aroop Mohanty Vijay Kumar Chattu Marjan Assefi Bijaya K. Padhi Ranjit Sah |
| author_sort | Sumira Malik |
| collection | DOAJ |
| description | The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed the urgent need for the development of a systematic protocol to produce Ebola vaccines prior to an outbreak. There are several vaccines available being developed by preclinical trials and human-based clinical trials. The group of vaccines includes virus-like particle-based vaccines, DNA-based vaccines, whole virus recombinant vaccines, incompetent replication originated vaccines, and competent replication vaccines. The limitations and challenges faced in the development of Ebola vaccines are the selection of immunogenic, rapid-responsive, cross-protective immunity-based vaccinations with assurances of prolonged protection. Another issue for the manufacturing and distribution of vaccines involves post authorization, licensing, and surveillance to ensure a vaccine’s efficacy towards combating the Ebola outbreak. The current review focuses on the development process, the current perspective on the development of an Ebola vaccine, and future challenges for combatting future emerging Ebola infectious disease. |
| first_indexed | 2024-03-11T08:02:56Z |
| format | Article |
| id | doaj.art-8044340e5f9b4d80807f3c4a9684f125 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T08:02:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8044340e5f9b4d80807f3c4a9684f1252023-11-16T23:42:04ZengMDPI AGVaccines2076-393X2023-01-0111226810.3390/vaccines11020268Ebola Virus Disease Vaccines: Development, Current Perspectives & ChallengesSumira Malik0Shristi Kishore1Sagnik Nag2Archna Dhasmana3Subham Preetam4Oishi Mitra5Darwin A. León-Figueroa6Aroop Mohanty7Vijay Kumar Chattu8Marjan Assefi9Bijaya K. Padhi10Ranjit Sah11Amity Institute of Biotechnology, Amity University Jharkhand, Ranchi 834001, Jharkhand, IndiaAmity Institute of Biotechnology, Amity University Jharkhand, Ranchi 834001, Jharkhand, IndiaDepartment of Biotechnology, School of Biosciences & Technology, Vellore Institute of Technology (VIT), Tiruvalam Road, Vellore 632014, Tamil Nadu, IndiaHimalayan School of Biosciences, Swami Rama Himalayan University, Jolly Grant, Dehradun 248140, Uttarakhand, IndiaInstitute of Advanced Materials, IAAM, Gammalkilsvägen 18, 59053 Ulrika, SwedenDepartment of Biotechnology, School of Biosciences & Technology, Vellore Institute of Technology (VIT), Tiruvalam Road, Vellore 632014, Tamil Nadu, IndiaFacultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo 15011, PeruDepartment of Microbiology, All India Institute of Medical Sciences, Gorakhpur 273008, Uttar Pradesh, IndiaDepartment of Occupational Science & Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaJoint School of NanoScience and Nano Engineering, University of North Carolina, Greensboro, NC 27402-6170, USADepartment of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, Punjab, IndiaTribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu 44600, NepalThe global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed the urgent need for the development of a systematic protocol to produce Ebola vaccines prior to an outbreak. There are several vaccines available being developed by preclinical trials and human-based clinical trials. The group of vaccines includes virus-like particle-based vaccines, DNA-based vaccines, whole virus recombinant vaccines, incompetent replication originated vaccines, and competent replication vaccines. The limitations and challenges faced in the development of Ebola vaccines are the selection of immunogenic, rapid-responsive, cross-protective immunity-based vaccinations with assurances of prolonged protection. Another issue for the manufacturing and distribution of vaccines involves post authorization, licensing, and surveillance to ensure a vaccine’s efficacy towards combating the Ebola outbreak. The current review focuses on the development process, the current perspective on the development of an Ebola vaccine, and future challenges for combatting future emerging Ebola infectious disease.https://www.mdpi.com/2076-393X/11/2/268Ebola virus disease (EVD)Ebola vaccinesEbola outbreakchallenges |
| spellingShingle | Sumira Malik Shristi Kishore Sagnik Nag Archna Dhasmana Subham Preetam Oishi Mitra Darwin A. León-Figueroa Aroop Mohanty Vijay Kumar Chattu Marjan Assefi Bijaya K. Padhi Ranjit Sah Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges Vaccines Ebola virus disease (EVD) Ebola vaccines Ebola outbreak challenges |
| title | Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges |
| title_full | Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges |
| title_fullStr | Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges |
| title_full_unstemmed | Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges |
| title_short | Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges |
| title_sort | ebola virus disease vaccines development current perspectives challenges |
| topic | Ebola virus disease (EVD) Ebola vaccines Ebola outbreak challenges |
| url | https://www.mdpi.com/2076-393X/11/2/268 |
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