A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina
Acute lymphoblastic leukemia (ALL) is a malignant disease caused by mutations in B- or T-cell precursors of bone marrow cells. Childhood acute lymphoblastic leukemia (ALL) is a subtype of pediatric cancer with a 1 in 2000 incidence. Here we present a new childhood ALL in a 3-year-old girl. As CD45/1...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2023-04-01
|
| Series: | Acta Medica Bulgarica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amb-2023-0009 |
| _version_ | 1797848591141699584 |
|---|---|
| author | Graiqevci-Uka V. Behluli E. Spahiu L. Liehr T. Temaj G. |
| author_facet | Graiqevci-Uka V. Behluli E. Spahiu L. Liehr T. Temaj G. |
| author_sort | Graiqevci-Uka V. |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is a malignant disease caused by mutations in B- or T-cell precursors of bone marrow cells. Childhood acute lymphoblastic leukemia (ALL) is a subtype of pediatric cancer with a 1 in 2000 incidence. Here we present a new childhood ALL in a 3-year-old girl. As CD45/19, CD10/19, CD3, CD8, CD10, and CD19 were positive in immunohistochemically analyses of blast cells, a B-ALL was diagnosed with a causative ETV6-RUNX1 gene fusion. The patient was treated based on standard protocols BMF-ALL 2009. Interestingly, an aunt and a grandfather of the patient had experienced malignancies as well, which may be carefully interpreted as a hint on a familial cancer syndrome. |
| first_indexed | 2024-04-09T18:30:59Z |
| format | Article |
| id | doaj.art-8044e98f88024d99992bccf73899faca |
| institution | Directory Open Access Journal |
| issn | 2719-5384 |
| language | English |
| last_indexed | 2024-04-09T18:30:59Z |
| publishDate | 2023-04-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj.art-8044e98f88024d99992bccf73899faca2023-04-11T17:07:21ZengSciendoActa Medica Bulgarica2719-53842023-04-01501596210.2478/amb-2023-0009A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from PristinaGraiqevci-Uka V.0Behluli E.1Spahiu L.2Liehr T.3Temaj G.41Department of Pediatric, University Clinical Center, Prishtina – Kosovo, United States1Department of Pediatric, University Clinical Center, Prishtina – Kosovo, United States1Department of Pediatric, University Clinical Center, Prishtina – Kosovo, United States2Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena – Germany3College UBT, Faculty of Pharmacy, Prishtina – Kosovo, United StatesAcute lymphoblastic leukemia (ALL) is a malignant disease caused by mutations in B- or T-cell precursors of bone marrow cells. Childhood acute lymphoblastic leukemia (ALL) is a subtype of pediatric cancer with a 1 in 2000 incidence. Here we present a new childhood ALL in a 3-year-old girl. As CD45/19, CD10/19, CD3, CD8, CD10, and CD19 were positive in immunohistochemically analyses of blast cells, a B-ALL was diagnosed with a causative ETV6-RUNX1 gene fusion. The patient was treated based on standard protocols BMF-ALL 2009. Interestingly, an aunt and a grandfather of the patient had experienced malignancies as well, which may be carefully interpreted as a hint on a familial cancer syndrome.https://doi.org/10.2478/amb-2023-0009acute lymphoblastic leukemiacancer syndromechildhood gene fusion |
| spellingShingle | Graiqevci-Uka V. Behluli E. Spahiu L. Liehr T. Temaj G. A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina Acta Medica Bulgarica acute lymphoblastic leukemia cancer syndrome childhood gene fusion |
| title | A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina |
| title_full | A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina |
| title_fullStr | A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina |
| title_full_unstemmed | A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina |
| title_short | A New Case of Childhood Acute Lymphoblastic B-Cell Leukemia from Pristina |
| title_sort | new case of childhood acute lymphoblastic b cell leukemia from pristina |
| topic | acute lymphoblastic leukemia cancer syndrome childhood gene fusion |
| url | https://doi.org/10.2478/amb-2023-0009 |
| work_keys_str_mv | AT graiqevciukav anewcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT behlulie anewcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT spahiul anewcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT liehrt anewcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT temajg anewcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT graiqevciukav newcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT behlulie newcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT spahiul newcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT liehrt newcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina AT temajg newcaseofchildhoodacutelymphoblasticbcellleukemiafrompristina |