Integration of locomotion and auditory signals in the mouse inferior colliculus
The inferior colliculus (IC) is the major midbrain auditory integration center, where virtually all ascending auditory inputs converge. Although the IC has been extensively studied for sound processing, little is known about the neural activity of the IC in moving subjects, as frequently happens in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-01-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/52228 |
| _version_ | 1811253018604077056 |
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| author | Yoonsun Yang Joonyeol Lee Gunsoo Kim |
| author_facet | Yoonsun Yang Joonyeol Lee Gunsoo Kim |
| author_sort | Yoonsun Yang |
| collection | DOAJ |
| description | The inferior colliculus (IC) is the major midbrain auditory integration center, where virtually all ascending auditory inputs converge. Although the IC has been extensively studied for sound processing, little is known about the neural activity of the IC in moving subjects, as frequently happens in natural hearing conditions. Here, by recording neural activity in walking mice, we show that the activity of IC neurons is strongly modulated by locomotion, even in the absence of sound stimuli. Similar modulation was also found in hearing-impaired mice, demonstrating that IC neurons receive non-auditory, locomotion-related neural signals. Sound-evoked activity was attenuated during locomotion, and this attenuation increased frequency selectivity across the neuronal population, while maintaining preferred frequencies. Our results suggest that during behavior, integrating movement-related and auditory information is an essential aspect of sound processing in the IC. |
| first_indexed | 2024-04-12T16:43:23Z |
| format | Article |
| id | doaj.art-80452ebaf41b4203a1699493e0350463 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:43:23Z |
| publishDate | 2020-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-80452ebaf41b4203a1699493e03504632022-12-22T03:24:41ZengeLife Sciences Publications LtdeLife2050-084X2020-01-01910.7554/eLife.52228Integration of locomotion and auditory signals in the mouse inferior colliculusYoonsun Yang0Joonyeol Lee1https://orcid.org/0000-0001-9929-6080Gunsoo Kim2https://orcid.org/0000-0001-9318-8329Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea; Department of Physiology, School of Medicine, Sungkyunkwan University, Suwon, Republic of KoreaCenter for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of KoreaCenter for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of KoreaThe inferior colliculus (IC) is the major midbrain auditory integration center, where virtually all ascending auditory inputs converge. Although the IC has been extensively studied for sound processing, little is known about the neural activity of the IC in moving subjects, as frequently happens in natural hearing conditions. Here, by recording neural activity in walking mice, we show that the activity of IC neurons is strongly modulated by locomotion, even in the absence of sound stimuli. Similar modulation was also found in hearing-impaired mice, demonstrating that IC neurons receive non-auditory, locomotion-related neural signals. Sound-evoked activity was attenuated during locomotion, and this attenuation increased frequency selectivity across the neuronal population, while maintaining preferred frequencies. Our results suggest that during behavior, integrating movement-related and auditory information is an essential aspect of sound processing in the IC.https://elifesciences.org/articles/52228auditoryinferior colliculusmouselocomotion |
| spellingShingle | Yoonsun Yang Joonyeol Lee Gunsoo Kim Integration of locomotion and auditory signals in the mouse inferior colliculus eLife auditory inferior colliculus mouse locomotion |
| title | Integration of locomotion and auditory signals in the mouse inferior colliculus |
| title_full | Integration of locomotion and auditory signals in the mouse inferior colliculus |
| title_fullStr | Integration of locomotion and auditory signals in the mouse inferior colliculus |
| title_full_unstemmed | Integration of locomotion and auditory signals in the mouse inferior colliculus |
| title_short | Integration of locomotion and auditory signals in the mouse inferior colliculus |
| title_sort | integration of locomotion and auditory signals in the mouse inferior colliculus |
| topic | auditory inferior colliculus mouse locomotion |
| url | https://elifesciences.org/articles/52228 |
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