Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance

Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance

Abstract Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal. Herein, a nanosystem was built based on cascade catalytic consumption of cholesterol. Cholesterol oxid...

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Bibliographic Details
Main Authors: Bin Du, Mei Zheng, Huizhen Ma, Jingshu Huang, Qingqing Jiao, Yimeng Bai, Mengmeng Zhao, Jie Zhou
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Nanobiotechnology
Subjects:
Cholesterol oxidase
Fluidity
Cholesterol
Lipid raft
Chondroitin sulfate
Apoptosis
Online Access:https://doi.org/10.1186/s12951-022-01406-9

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