New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation
In the last decade, adipose tissue has emerged as an endocrine organ with a key role in energy homeostasis. In addition, there is close crosstalk between the adipose tissue and the liver, since pro- and anti-inflammatory substances produced at the visceral adipose tissue level directly target the li...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/9/1100 |
| _version_ | 1827839016858288128 |
|---|---|
| author | María Eugenia Cornide-Petronio Mónica B. Jiménez-Castro Jordi Gracia-Sancho Carmen Peralta |
| author_facet | María Eugenia Cornide-Petronio Mónica B. Jiménez-Castro Jordi Gracia-Sancho Carmen Peralta |
| author_sort | María Eugenia Cornide-Petronio |
| collection | DOAJ |
| description | In the last decade, adipose tissue has emerged as an endocrine organ with a key role in energy homeostasis. In addition, there is close crosstalk between the adipose tissue and the liver, since pro- and anti-inflammatory substances produced at the visceral adipose tissue level directly target the liver through the portal vein. During surgical procedures, including hepatic resection and liver transplantation, ischemia−reperfusion injury induces damage and regenerative failure. It has been suggested that adipose tissue is associated with both pathological or, on the contrary, with protective effects on damage and regenerative response after liver surgery. The present review aims to summarize the current knowledge on the crosstalk between the adipose tissue and the liver during liver surgery. Therapeutic strategies as well as the clinical and scientific controversies in this field are discussed. The different experimental models, such as lipectomy, to evaluate the role of adipose tissue in both steatotic and nonsteatotic livers undergoing surgery, are described. Such information may be useful for the establishment of protective strategies aimed at regulating the liver−visceral adipose tissue axis and improving the postoperative outcomes in clinical liver surgery. |
| first_indexed | 2024-03-12T07:15:23Z |
| format | Article |
| id | doaj.art-8046fffd4d414a2cb348325b9a5d4b63 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:15:23Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8046fffd4d414a2cb348325b9a5d4b632023-09-02T22:52:39ZengMDPI AGCells2073-44092019-09-0189110010.3390/cells8091100cells8091100New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver TransplantationMaría Eugenia Cornide-Petronio0Mónica B. Jiménez-Castro1Jordi Gracia-Sancho2Carmen Peralta3Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, SpainLiver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Laboratory IDIBAPS, 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, SpainIn the last decade, adipose tissue has emerged as an endocrine organ with a key role in energy homeostasis. In addition, there is close crosstalk between the adipose tissue and the liver, since pro- and anti-inflammatory substances produced at the visceral adipose tissue level directly target the liver through the portal vein. During surgical procedures, including hepatic resection and liver transplantation, ischemia−reperfusion injury induces damage and regenerative failure. It has been suggested that adipose tissue is associated with both pathological or, on the contrary, with protective effects on damage and regenerative response after liver surgery. The present review aims to summarize the current knowledge on the crosstalk between the adipose tissue and the liver during liver surgery. Therapeutic strategies as well as the clinical and scientific controversies in this field are discussed. The different experimental models, such as lipectomy, to evaluate the role of adipose tissue in both steatotic and nonsteatotic livers undergoing surgery, are described. Such information may be useful for the establishment of protective strategies aimed at regulating the liver−visceral adipose tissue axis and improving the postoperative outcomes in clinical liver surgery.https://www.mdpi.com/2073-4409/8/9/1100adipose tissueliverinflammationsteatosisliver resectionliver transplantationlipectomy |
| spellingShingle | María Eugenia Cornide-Petronio Mónica B. Jiménez-Castro Jordi Gracia-Sancho Carmen Peralta New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation Cells adipose tissue liver inflammation steatosis liver resection liver transplantation lipectomy |
| title | New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation |
| title_full | New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation |
| title_fullStr | New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation |
| title_full_unstemmed | New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation |
| title_short | New Insights into the Liver–Visceral Adipose Axis During Hepatic Resection and Liver Transplantation |
| title_sort | new insights into the liver visceral adipose axis during hepatic resection and liver transplantation |
| topic | adipose tissue liver inflammation steatosis liver resection liver transplantation lipectomy |
| url | https://www.mdpi.com/2073-4409/8/9/1100 |
| work_keys_str_mv | AT mariaeugeniacornidepetronio newinsightsintothelivervisceraladiposeaxisduringhepaticresectionandlivertransplantation AT monicabjimenezcastro newinsightsintothelivervisceraladiposeaxisduringhepaticresectionandlivertransplantation AT jordigraciasancho newinsightsintothelivervisceraladiposeaxisduringhepaticresectionandlivertransplantation AT carmenperalta newinsightsintothelivervisceraladiposeaxisduringhepaticresectionandlivertransplantation |