Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional DyspepsiaSummary

Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional DyspepsiaSummary

Background & Aims: Acid hypersensitivity is claimed to be a symptomatic trigger in functional dyspepsia (FD); however, the neuroimmune pathway(s) and the mediators involved in this process have not been investigated systematically. Palmitoylethanolamide (PEA) is an endogenous compound, able...

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Bibliographic Details
Main Authors: Giovanni Sarnelli, Marcella Pesce, Luisa Seguella, Jie Lu, Eleonora Efficie, Jan Tack, Fatima Domenica Elisa De Palma, Alessandra D’Alessandro, Giuseppe Esposito
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Functional Dyspepsia
Duodenal Mucosa
Mast Cells
Enteric Nervous System
Visceral Hypersensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301612

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