Pathogenetic therapy of COVID-19: focus on glucocorticoids
The problem of preventing excessive production of pro-inflammatory cytokines in the case of COVID-19 remains unresolved. The use of steroids in the treatment of coronavirus pneumonia remains controversial. To date, there is insufficient literature data for the routine use of steroids in COVID-19 int...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2022-04-01
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| Series: | Медицина неотложных состояний |
| Subjects: | |
| Online Access: | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1466 |
| _version_ | 1811154268716007424 |
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| author | M.V. Bondar M.M. Pilipenko T.V. Ovsiienko O.A. Loskutov |
| author_facet | M.V. Bondar M.M. Pilipenko T.V. Ovsiienko O.A. Loskutov |
| author_sort | M.V. Bondar |
| collection | DOAJ |
| description | The problem of preventing excessive production of pro-inflammatory cytokines in the case of COVID-19 remains unresolved. The use of steroids in the treatment of coronavirus pneumonia remains controversial. To date, there is insufficient literature data for the routine use of steroids in COVID-19 intensive care programs, and this issue remains the subject of continuous research and endless debate. The review of the scientific literature focuses on one of the areas of pathogenetic therapy for COVID-19 — the prevention and elimination of hyperproduction of pro-inflammatory cytokines using glucocorticoid drugs. The review presents modern international recommendations on the use of glucocorticoid drugs in severe COVID-19, examines the pathogenetic mechanisms of their action and side effects. |
| first_indexed | 2024-04-10T04:12:48Z |
| format | Article |
| id | doaj.art-80495ba6767c4c0593e74614ff1a1a71 |
| institution | Directory Open Access Journal |
| issn | 2224-0586 2307-1230 |
| language | English |
| last_indexed | 2024-04-10T04:12:48Z |
| publishDate | 2022-04-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Медицина неотложных состояний |
| spelling | doaj.art-80495ba6767c4c0593e74614ff1a1a712023-03-12T14:46:38ZengZaslavsky O.Yu.Медицина неотложных состояний2224-05862307-12302022-04-0118261210.22141/2224-0586.18.2.2022.14661466Pathogenetic therapy of COVID-19: focus on glucocorticoidsM.V. Bondar0M.M. Pilipenko1T.V. Ovsiienko2O.A. Loskutov3https://orcid.org/0000-0002-7646-9193Національний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, УкраїнаНаціональний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, УкраїнаНаціональний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, Україна; ДУ «Інститут урології імені академіка О.Ф. Возіанова» НАМН України, м. Київ, УкраїнаНаціональний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, УкраїнаThe problem of preventing excessive production of pro-inflammatory cytokines in the case of COVID-19 remains unresolved. The use of steroids in the treatment of coronavirus pneumonia remains controversial. To date, there is insufficient literature data for the routine use of steroids in COVID-19 intensive care programs, and this issue remains the subject of continuous research and endless debate. The review of the scientific literature focuses on one of the areas of pathogenetic therapy for COVID-19 — the prevention and elimination of hyperproduction of pro-inflammatory cytokines using glucocorticoid drugs. The review presents modern international recommendations on the use of glucocorticoid drugs in severe COVID-19, examines the pathogenetic mechanisms of their action and side effects.https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1466covid-19systemic inflammatory responsepro-inflammatory cytokineshypothalamo-pituitary-adrenal systemglucocorticoidsreview |
| spellingShingle | M.V. Bondar M.M. Pilipenko T.V. Ovsiienko O.A. Loskutov Pathogenetic therapy of COVID-19: focus on glucocorticoids Медицина неотложных состояний covid-19 systemic inflammatory response pro-inflammatory cytokines hypothalamo-pituitary-adrenal system glucocorticoids review |
| title | Pathogenetic therapy of COVID-19: focus on glucocorticoids |
| title_full | Pathogenetic therapy of COVID-19: focus on glucocorticoids |
| title_fullStr | Pathogenetic therapy of COVID-19: focus on glucocorticoids |
| title_full_unstemmed | Pathogenetic therapy of COVID-19: focus on glucocorticoids |
| title_short | Pathogenetic therapy of COVID-19: focus on glucocorticoids |
| title_sort | pathogenetic therapy of covid 19 focus on glucocorticoids |
| topic | covid-19 systemic inflammatory response pro-inflammatory cytokines hypothalamo-pituitary-adrenal system glucocorticoids review |
| url | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1466 |
| work_keys_str_mv | AT mvbondar pathogenetictherapyofcovid19focusonglucocorticoids AT mmpilipenko pathogenetictherapyofcovid19focusonglucocorticoids AT tvovsiienko pathogenetictherapyofcovid19focusonglucocorticoids AT oaloskutov pathogenetictherapyofcovid19focusonglucocorticoids |