Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer
Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=5;spage=662;epage=672;aulast=Landau |
| _version_ | 1818564783654305792 |
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| author | Kevin S Landau Insung Na Ryan O Schenck Vladimir N Uversky |
| author_facet | Kevin S Landau Insung Na Ryan O Schenck Vladimir N Uversky |
| author_sort | Kevin S Landau |
| collection | DOAJ |
| description | Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease. |
| first_indexed | 2024-12-14T01:33:06Z |
| format | Article |
| id | doaj.art-804b4ffc5a1c42eab71e2a99c49fa3e2 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-14T01:33:06Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-804b4ffc5a1c42eab71e2a99c49fa3e22022-12-21T23:21:59ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622016-01-0118566267210.4103/1008-682X.184999Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancerKevin S LandauInsung NaRyan O SchenckVladimir N UverskyProstatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=5;spage=662;epage=672;aulast=Landauintrinsically disordered proteins; posttranslational modifications; prostate cancer; protein-protein interaction; proteomics; proteome; unfoldome |
| spellingShingle | Kevin S Landau Insung Na Ryan O Schenck Vladimir N Uversky Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer Asian Journal of Andrology intrinsically disordered proteins; posttranslational modifications; prostate cancer; protein-protein interaction; proteomics; proteome; unfoldome |
| title | Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| title_full | Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| title_fullStr | Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| title_full_unstemmed | Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| title_short | Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| title_sort | unfoldomics of prostate cancer on the abundance and roles of intrinsically disordered proteins in prostate cancer |
| topic | intrinsically disordered proteins; posttranslational modifications; prostate cancer; protein-protein interaction; proteomics; proteome; unfoldome |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=5;spage=662;epage=672;aulast=Landau |
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