Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats
Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, spe...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2019-05-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| _version_ | 1828873587111493632 |
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| author | Cem Yucel Fatma Demet Arslan Sumeyye Ekmekci Volkan Ulker Erdem Kisa Elcin Erdogan Yucel Murat Ucar Yusuf Ozlem Ilbey Orcun Celik Banu Isbilen Basok Zafer Kozacioglu |
| author_facet | Cem Yucel Fatma Demet Arslan Sumeyye Ekmekci Volkan Ulker Erdem Kisa Elcin Erdogan Yucel Murat Ucar Yusuf Ozlem Ilbey Orcun Celik Banu Isbilen Basok Zafer Kozacioglu |
| author_sort | Cem Yucel |
| collection | DOAJ |
| description | Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats.
Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups.
Results: The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score.
Conclusions: The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA. |
| first_indexed | 2024-12-13T07:20:11Z |
| format | Article |
| id | doaj.art-804cef4c7fed4e19afdeed9867441bf4 |
| institution | Directory Open Access Journal |
| issn | 2287-4208 2287-4690 |
| language | English |
| last_indexed | 2024-12-13T07:20:11Z |
| publishDate | 2019-05-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj.art-804cef4c7fed4e19afdeed9867441bf42022-12-21T23:55:27ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902019-05-0137224925610.5534/wjmh.180105Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in RatsCem Yucel0Fatma Demet Arslan1Sumeyye Ekmekci2Volkan Ulker3Erdem Kisa4Elcin Erdogan Yucel5Murat Ucar6Yusuf Ozlem Ilbey7Orcun Celik8Banu Isbilen Basok9Zafer Kozacioglu10Tepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyTepecik Training and Research Hospital, Izmir, TurkeyPurpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. Results: The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. Conclusions: The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.CisplatinOxidative stressSpermatogenesisTestisVitamin A |
| spellingShingle | Cem Yucel Fatma Demet Arslan Sumeyye Ekmekci Volkan Ulker Erdem Kisa Elcin Erdogan Yucel Murat Ucar Yusuf Ozlem Ilbey Orcun Celik Banu Isbilen Basok Zafer Kozacioglu Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats The World Journal of Men's Health Cisplatin Oxidative stress Spermatogenesis Testis Vitamin A |
| title | Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats |
| title_full | Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats |
| title_fullStr | Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats |
| title_full_unstemmed | Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats |
| title_short | Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats |
| title_sort | protective effect of all trans retinoic acid in cisplatin induced testicular damage in rats |
| topic | Cisplatin Oxidative stress Spermatogenesis Testis Vitamin A |
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