Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-03-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3946368?pdf=render |
| _version_ | 1828527699497320448 |
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| author | Cecile Le Saout Rebecca B Hasley Hiromi Imamichi Lueng Tcheung Zonghui Hu Megan A Luckey Jung-Hyun Park Scott K Durum Mindy Smith Adam W Rupert Michael C Sneller H Clifford Lane Marta Catalfamo |
| author_facet | Cecile Le Saout Rebecca B Hasley Hiromi Imamichi Lueng Tcheung Zonghui Hu Megan A Luckey Jung-Hyun Park Scott K Durum Mindy Smith Adam W Rupert Michael C Sneller H Clifford Lane Marta Catalfamo |
| author_sort | Cecile Le Saout |
| collection | DOAJ |
| description | HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we addressed the impact of lymphopenia and chronic exposure to IFN-α on T cell homeostasis. In a lymphopenic murine model, this interaction led to decreased CD4 counts and CD8 T cell expansion in association with an increase in the Signal Transducer and Activator of Transcription 1 (STAT1) levels resulting in enhanced CD4 T cell responsiveness to IFN-α. Thus, in the setting of HIV infection, chronic stimulation of this pathway could be detrimental for CD4 T cell homeostasis. |
| first_indexed | 2024-12-11T21:41:56Z |
| format | Article |
| id | doaj.art-804d6b2f4d244404a891121e7c82ffb4 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-11T21:41:56Z |
| publishDate | 2014-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-804d6b2f4d244404a891121e7c82ffb42022-12-22T00:49:48ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742014-03-01103e100397610.1371/journal.ppat.1003976Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.Cecile Le SaoutRebecca B HasleyHiromi ImamichiLueng TcheungZonghui HuMegan A LuckeyJung-Hyun ParkScott K DurumMindy SmithAdam W RupertMichael C SnellerH Clifford LaneMarta CatalfamoHIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we addressed the impact of lymphopenia and chronic exposure to IFN-α on T cell homeostasis. In a lymphopenic murine model, this interaction led to decreased CD4 counts and CD8 T cell expansion in association with an increase in the Signal Transducer and Activator of Transcription 1 (STAT1) levels resulting in enhanced CD4 T cell responsiveness to IFN-α. Thus, in the setting of HIV infection, chronic stimulation of this pathway could be detrimental for CD4 T cell homeostasis.http://europepmc.org/articles/PMC3946368?pdf=render |
| spellingShingle | Cecile Le Saout Rebecca B Hasley Hiromi Imamichi Lueng Tcheung Zonghui Hu Megan A Luckey Jung-Hyun Park Scott K Durum Mindy Smith Adam W Rupert Michael C Sneller H Clifford Lane Marta Catalfamo Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathogens |
| title | Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. |
| title_full | Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. |
| title_fullStr | Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. |
| title_full_unstemmed | Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. |
| title_short | Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. |
| title_sort | chronic exposure to type i ifn under lymphopenic conditions alters cd4 t cell homeostasis |
| url | http://europepmc.org/articles/PMC3946368?pdf=render |
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