Regulation of short-chain fatty acids in the immune system
A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role in the health status of symbiotes. SCFAs act on a variety of cell types to regulate important biological processes, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186892/full |
| _version_ | 1797833048658542592 |
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| author | Xiao-feng Liu Jia-hao Shao Yi-Tao Liao Li-Ning Wang Yuan Jia Peng-jun Dong Zhi-zhong Liu Dan-dan He Chao Li Xian Zhang |
| author_facet | Xiao-feng Liu Jia-hao Shao Yi-Tao Liao Li-Ning Wang Yuan Jia Peng-jun Dong Zhi-zhong Liu Dan-dan He Chao Li Xian Zhang |
| author_sort | Xiao-feng Liu |
| collection | DOAJ |
| description | A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role in the health status of symbiotes. SCFAs act on a variety of cell types to regulate important biological processes, including host metabolism, intestinal function, and immune function. SCFAs also affect the function and fate of immune cells. This finding provides a new concept in immune metabolism and a better understanding of the regulatory role of SCFAs in the immune system, which impacts the prevention and treatment of disease. The mechanism by which SCFAs induce or regulate the immune response is becoming increasingly clear. This review summarizes the different mechanisms through which SCFAs act in cells. According to the latest research, the regulatory role of SCFAs in the innate immune system, including in NLRP3 inflammasomes, receptors of TLR family members, neutrophils, macrophages, natural killer cells, eosinophils, basophils and innate lymphocyte subsets, is emphasized. The regulatory role of SCFAs in the adaptive immune system, including in T-cell subsets, B cells, and plasma cells, is also highlighted. In addition, we discuss the role that SCFAs play in regulating allergic airway inflammation, colitis, and osteoporosis by influencing the immune system. These findings provide evidence for determining treatment options based on metabolic regulation. |
| first_indexed | 2024-04-09T14:17:27Z |
| format | Article |
| id | doaj.art-804d79d28c754f959124e52176c80ee1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T14:17:27Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-804d79d28c754f959124e52176c80ee12023-05-05T05:54:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11868921186892Regulation of short-chain fatty acids in the immune systemXiao-feng Liu0Jia-hao Shao1Yi-Tao Liao2Li-Ning Wang3Yuan Jia4Peng-jun Dong5Zhi-zhong Liu6Dan-dan He7Chao Li8Xian Zhang9Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaSchool of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaWuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaDepartment of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaDepartment of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, ChinaA growing body of research suggests that short-chain fatty acids (SCFAs), metabolites produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role in the health status of symbiotes. SCFAs act on a variety of cell types to regulate important biological processes, including host metabolism, intestinal function, and immune function. SCFAs also affect the function and fate of immune cells. This finding provides a new concept in immune metabolism and a better understanding of the regulatory role of SCFAs in the immune system, which impacts the prevention and treatment of disease. The mechanism by which SCFAs induce or regulate the immune response is becoming increasingly clear. This review summarizes the different mechanisms through which SCFAs act in cells. According to the latest research, the regulatory role of SCFAs in the innate immune system, including in NLRP3 inflammasomes, receptors of TLR family members, neutrophils, macrophages, natural killer cells, eosinophils, basophils and innate lymphocyte subsets, is emphasized. The regulatory role of SCFAs in the adaptive immune system, including in T-cell subsets, B cells, and plasma cells, is also highlighted. In addition, we discuss the role that SCFAs play in regulating allergic airway inflammation, colitis, and osteoporosis by influencing the immune system. These findings provide evidence for determining treatment options based on metabolic regulation.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186892/fullshort-chain fatty acidinnate immunityadaptive immunityhistone deacetylaseG-protein-coupled receptor |
| spellingShingle | Xiao-feng Liu Jia-hao Shao Yi-Tao Liao Li-Ning Wang Yuan Jia Peng-jun Dong Zhi-zhong Liu Dan-dan He Chao Li Xian Zhang Regulation of short-chain fatty acids in the immune system Frontiers in Immunology short-chain fatty acid innate immunity adaptive immunity histone deacetylase G-protein-coupled receptor |
| title | Regulation of short-chain fatty acids in the immune system |
| title_full | Regulation of short-chain fatty acids in the immune system |
| title_fullStr | Regulation of short-chain fatty acids in the immune system |
| title_full_unstemmed | Regulation of short-chain fatty acids in the immune system |
| title_short | Regulation of short-chain fatty acids in the immune system |
| title_sort | regulation of short chain fatty acids in the immune system |
| topic | short-chain fatty acid innate immunity adaptive immunity histone deacetylase G-protein-coupled receptor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186892/full |
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