Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The h...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-02-01
|
| Series: | Nanotechnology Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/ntrev-2021-0002 |
| _version_ | 1818344587005001728 |
|---|---|
| author | Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue |
| author_facet | Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue |
| author_sort | Gu Xinyi |
| collection | DOAJ |
| description | Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration. |
| first_indexed | 2024-12-13T16:48:50Z |
| format | Article |
| id | doaj.art-804da949a55044eea6350e42ca0c7660 |
| institution | Directory Open Access Journal |
| issn | 2191-9097 |
| language | English |
| last_indexed | 2024-12-13T16:48:50Z |
| publishDate | 2021-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-804da949a55044eea6350e42ca0c76602022-12-21T23:38:06ZengDe GruyterNanotechnology Reviews2191-90972021-02-01101101910.1515/ntrev-2021-0002Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regenerationGu Xinyi0Chen Xiaoli1Tang Xiaoxuan2Zhou Zhihao3Huang Tingting4Yang Yumin5Ling Jue6Key Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaKey Laboratory of Neuroregeneration, Neural Regeneration Co-Innovation Centre of Jiangsu Province, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, ChinaSuccessful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.https://doi.org/10.1515/ntrev-2021-0002silk fibroinhydrogelmicropatternperipheral nerve regeneration |
| spellingShingle | Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration Nanotechnology Reviews silk fibroin hydrogel micropattern peripheral nerve regeneration |
| title | Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| title_full | Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| title_fullStr | Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| title_full_unstemmed | Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| title_short | Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| title_sort | pure silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration |
| topic | silk fibroin hydrogel micropattern peripheral nerve regeneration |
| url | https://doi.org/10.1515/ntrev-2021-0002 |
| work_keys_str_mv | AT guxinyi puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT chenxiaoli puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT tangxiaoxuan puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT zhouzhihao puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT huangtingting puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT yangyumin puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT lingjue puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration |