Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg
The aim is to evaluate the sensitivity, specificity and positive predictive value of ALEX2 Allergy Explorer test in patients suffering from atopic dermatitis and reactions to egg. We compared the results of specific IgE to allergen reagents (molecular components) with reactions to egg in the open ex...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09540105.2022.2085672 |
| _version_ | 1818116705242578944 |
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| author | J. Čelakovská E. Cermakova R. Vaňková P. Boudkova J. Krejsek C. Andrýs |
| author_facet | J. Čelakovská E. Cermakova R. Vaňková P. Boudkova J. Krejsek C. Andrýs |
| author_sort | J. Čelakovská |
| collection | DOAJ |
| description | The aim is to evaluate the sensitivity, specificity and positive predictive value of ALEX2 Allergy Explorer test in patients suffering from atopic dermatitis and reactions to egg. We compared the results of specific IgE to allergen reagents (molecular components) with reactions to egg in the open exposure test (OET) (history); the sensitivity, specificity and positive predictictive value were calculated with Fisher's Exact test. Altogether 100 atopic dermatitis patients were examined. The reaction to egg was confirmed in 19 patients (19%). We confirmed significant relation between the results of specific IgE to Gal d 1, Gal d 2, Gal d 3, Gal d 5, Gal d white and Gal d yolk and the results of the OET/history; the sensitivity is in the range 21.05–52.63%. We recommend to evaluate food allergy to egg in patients with severe atopic dermatitis even with negative specific IgE for molecular components. |
| first_indexed | 2024-12-11T04:26:45Z |
| format | Article |
| id | doaj.art-804ef90065674698b091cec076f00cd8 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-12-11T04:26:45Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-804ef90065674698b091cec076f00cd82022-12-22T01:20:58ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432022-12-0133143845010.1080/09540105.2022.2085672Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to eggJ. Čelakovská0E. Cermakova1R. Vaňková2P. Boudkova3J. Krejsek4C. Andrýs5Department of Dermatology and Venereology, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Medical Biophysic, Medical Faculty of Charles University, Hradec Králové, Czech republicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicDepartment of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech RepublicThe aim is to evaluate the sensitivity, specificity and positive predictive value of ALEX2 Allergy Explorer test in patients suffering from atopic dermatitis and reactions to egg. We compared the results of specific IgE to allergen reagents (molecular components) with reactions to egg in the open exposure test (OET) (history); the sensitivity, specificity and positive predictictive value were calculated with Fisher's Exact test. Altogether 100 atopic dermatitis patients were examined. The reaction to egg was confirmed in 19 patients (19%). We confirmed significant relation between the results of specific IgE to Gal d 1, Gal d 2, Gal d 3, Gal d 5, Gal d white and Gal d yolk and the results of the OET/history; the sensitivity is in the range 21.05–52.63%. We recommend to evaluate food allergy to egg in patients with severe atopic dermatitis even with negative specific IgE for molecular components.https://www.tandfonline.com/doi/10.1080/09540105.2022.2085672atopic dermatitismolecular componentsallergy to eggpositive predictive valueALEX2 multiplex examinationsensitivity |
| spellingShingle | J. Čelakovská E. Cermakova R. Vaňková P. Boudkova J. Krejsek C. Andrýs Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg Food and Agricultural Immunology atopic dermatitis molecular components allergy to egg positive predictive value ALEX2 multiplex examination sensitivity |
| title | Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| title_full | Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| title_fullStr | Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| title_full_unstemmed | Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| title_short | Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| title_sort | sensitivity specificity and positive predictive value of alex2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg |
| topic | atopic dermatitis molecular components allergy to egg positive predictive value ALEX2 multiplex examination sensitivity |
| url | https://www.tandfonline.com/doi/10.1080/09540105.2022.2085672 |
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