Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing
BackgroundBrain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. He...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00232/full |
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| author | Felicia von Düring Inka Ristow Meng Li Meng Li Dominik Denzel Lejla Colic Lejla Colic Lejla Colic Liliana Ramona Demenescu Shijia Li Shijia Li Viola Borchardt Viola Borchardt Thomas Liebe Matthias Vogel Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter |
| author_facet | Felicia von Düring Inka Ristow Meng Li Meng Li Dominik Denzel Lejla Colic Lejla Colic Lejla Colic Liliana Ramona Demenescu Shijia Li Shijia Li Viola Borchardt Viola Borchardt Thomas Liebe Matthias Vogel Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter |
| author_sort | Felicia von Düring |
| collection | DOAJ |
| description | BackgroundBrain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing.MethodsTwenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected or unexpected situations. Correlation between MRS and task fMRI was investigated by performing regression analyses controlling for age, gender, and gray matter partial volume.Results/ConclusionDuring picture processing, the extent of deactivation in the Posterior Cingulate Cortex (PCC) was attenuated by two different salience attributions: sexual content and unexpectedness of emotional content. Our results indicate that stimulus inherent salience induces an attenuation of the deactivation in PCC, which is in turn balanced by higher level of glutamate in the dACC. |
| first_indexed | 2024-12-10T04:19:23Z |
| format | Article |
| id | doaj.art-80539152d65b41bd8ce403bd49a1d049 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T04:19:23Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-80539152d65b41bd8ce403bd49a1d0492022-12-22T02:02:28ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-10-011310.3389/fnbeh.2019.00232481361Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience ProcessingFelicia von Düring0Inka Ristow1Meng Li2Meng Li3Dominik Denzel4Lejla Colic5Lejla Colic6Lejla Colic7Liliana Ramona Demenescu8Shijia Li9Shijia Li10Viola Borchardt11Viola Borchardt12Thomas Liebe13Matthias Vogel14Martin Walter15Martin Walter16Martin Walter17Martin Walter18Martin Walter19Martin Walter20Martin Walter21Clinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyMax Planck Institute for Biological Cybernetics, Tübingen, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyDepartment of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, GermanyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United StatesClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanySchool of Psychology and Cognitive Science, East China Normal University, Shanghai, ChinaClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyDepartment of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, GermanyClinical Affective Neuroimaging Laboratory, Otto von Guericke University Magdeburg, Magdeburg, GermanyMax Planck Institute for Biological Cybernetics, Tübingen, GermanyDepartment of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, GermanyDepartment of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, GermanyCenter for Behavioral Brain Sciences, Magdeburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany0Department of Psychiatry and Psychotherapy, University of Jena, Jena, GermanyBackgroundBrain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing.MethodsTwenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected or unexpected situations. Correlation between MRS and task fMRI was investigated by performing regression analyses controlling for age, gender, and gray matter partial volume.Results/ConclusionDuring picture processing, the extent of deactivation in the Posterior Cingulate Cortex (PCC) was attenuated by two different salience attributions: sexual content and unexpectedness of emotional content. Our results indicate that stimulus inherent salience induces an attenuation of the deactivation in PCC, which is in turn balanced by higher level of glutamate in the dACC.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00232/fullPCCfMRIMRSglutamatesalience attributionattention |
| spellingShingle | Felicia von Düring Inka Ristow Meng Li Meng Li Dominik Denzel Lejla Colic Lejla Colic Lejla Colic Liliana Ramona Demenescu Shijia Li Shijia Li Viola Borchardt Viola Borchardt Thomas Liebe Matthias Vogel Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Martin Walter Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing Frontiers in Behavioral Neuroscience PCC fMRI MRS glutamate salience attribution attention |
| title | Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing |
| title_full | Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing |
| title_fullStr | Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing |
| title_full_unstemmed | Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing |
| title_short | Glutamate in Salience Network Predicts BOLD Response in Default Mode Network During Salience Processing |
| title_sort | glutamate in salience network predicts bold response in default mode network during salience processing |
| topic | PCC fMRI MRS glutamate salience attribution attention |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00232/full |
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