The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8

The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8

ABSTRACT Replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is mediated by a complex of non-structural proteins (NSPs), of which NSP7 and NSP8 serve as subunits and play a key role in promoting the activity of RNA-dependent RNA polymerase (RdRp) of NSP12. However, the...

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Main Authors: Lujie Fan, Yuzheng Zhou, Xiafei Wei, Wei Feng, Huimin Guo, Yunfei Li, Xiang Gao, Jian Zhou, Yanling Wen, Yezi Wu, Xiaotong Shen, Lei Liu, Gang Xu, Zheng Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
SARS-CoV-2
NSP8
TRIM22
ubiquitination
protein degradation
Online Access:https://journals.asm.org/doi/10.1128/mbio.02320-23

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