Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution
Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/8/1282 |
| _version_ | 1797409401834831872 |
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| author | Xavier Eugenio León Aguilera Alexander Manzano Daniela Pirela Valmore Bermúdez |
| author_facet | Xavier Eugenio León Aguilera Alexander Manzano Daniela Pirela Valmore Bermúdez |
| author_sort | Xavier Eugenio León Aguilera |
| collection | DOAJ |
| description | Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of <i>Firmicutes</i>, a decrease in <i>Bifidobacterium</i> in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity. |
| first_indexed | 2024-03-09T04:14:06Z |
| format | Article |
| id | doaj.art-8054952ec152477098c08652b77afeab |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T04:14:06Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-8054952ec152477098c08652b77afeab2023-12-03T13:56:09ZengMDPI AGJournal of Personalized Medicine2075-44262022-08-01128128210.3390/jpm12081282Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health RevolutionXavier Eugenio León Aguilera0Alexander Manzano1Daniela Pirela2Valmore Bermúdez3Departamento de Post-Grado, Universidad Católica de Cuenca, Ciudad Cuenca 010109, EcuadorEndocrine and Metabolic Diseases Research Center, School of Medicine, Universidad del Zulia, Maracaibo 4002, VenezuelaEndocrine and Metabolic Diseases Research Center, School of Medicine, Universidad del Zulia, Maracaibo 4002, VenezuelaDepartamento de Post-Grado, Universidad Católica de Cuenca, Ciudad Cuenca 010109, EcuadorObesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of <i>Firmicutes</i>, a decrease in <i>Bifidobacterium</i> in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity.https://www.mdpi.com/2075-4426/12/8/1282obesitygut microbiotashort chain fatty acidsprobioticsprebiotics |
| spellingShingle | Xavier Eugenio León Aguilera Alexander Manzano Daniela Pirela Valmore Bermúdez Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution Journal of Personalized Medicine obesity gut microbiota short chain fatty acids probiotics prebiotics |
| title | Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution |
| title_full | Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution |
| title_fullStr | Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution |
| title_full_unstemmed | Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution |
| title_short | Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution |
| title_sort | probiotics and gut microbiota in obesity myths and realities of a new health revolution |
| topic | obesity gut microbiota short chain fatty acids probiotics prebiotics |
| url | https://www.mdpi.com/2075-4426/12/8/1282 |
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