δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling
Summary: The division of neural progenitor cells provides the cellular substrate from which the nervous system is sculpted during development. The δ-protocadherin family of homophilic cell adhesion molecules is essential for the development of the vertebrate nervous system and is implicated in an ar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221009007 |
| _version_ | 1818611542878322688 |
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| author | Sayantanee Biswas Michelle R. Emond Kurtis P. Chenoweth James D. Jontes |
| author_facet | Sayantanee Biswas Michelle R. Emond Kurtis P. Chenoweth James D. Jontes |
| author_sort | Sayantanee Biswas |
| collection | DOAJ |
| description | Summary: The division of neural progenitor cells provides the cellular substrate from which the nervous system is sculpted during development. The δ-protocadherin family of homophilic cell adhesion molecules is essential for the development of the vertebrate nervous system and is implicated in an array of neurodevelopmental disorders. We show that lesions in any of six, individual δ-protocadherins increases cell divisions of neural progenitors in the hindbrain. This increase is due to mis-regulation of Wnt/β-catenin signaling, as this pathway is upregulated in δ-protocadherin mutants and inhibition of this pathway blocks the increase in cell division. Furthermore, the δ-protocadherins can be present in complex with the Wnt receptor Ryk, and Ryk is required for the increased proliferation in protocadherin mutants. Thus, δ-protocadherins are novel regulators of Wnt/β-catenin signaling that may control the development of neural circuits by defining a molecular code for the identity of neural progenitor cells and differentially regulating their proliferation. |
| first_indexed | 2024-12-16T15:31:59Z |
| format | Article |
| id | doaj.art-8054bc8ec1d64d21869d9a3b3e3312fe |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-16T15:31:59Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-8054bc8ec1d64d21869d9a3b3e3312fe2022-12-21T22:26:18ZengElsevieriScience2589-00422021-08-01248102932δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signalingSayantanee Biswas0Michelle R. Emond1Kurtis P. Chenoweth2James D. Jontes3Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210 USADepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210 USADepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210 USADepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH 43210 USA; Corresponding authorSummary: The division of neural progenitor cells provides the cellular substrate from which the nervous system is sculpted during development. The δ-protocadherin family of homophilic cell adhesion molecules is essential for the development of the vertebrate nervous system and is implicated in an array of neurodevelopmental disorders. We show that lesions in any of six, individual δ-protocadherins increases cell divisions of neural progenitors in the hindbrain. This increase is due to mis-regulation of Wnt/β-catenin signaling, as this pathway is upregulated in δ-protocadherin mutants and inhibition of this pathway blocks the increase in cell division. Furthermore, the δ-protocadherins can be present in complex with the Wnt receptor Ryk, and Ryk is required for the increased proliferation in protocadherin mutants. Thus, δ-protocadherins are novel regulators of Wnt/β-catenin signaling that may control the development of neural circuits by defining a molecular code for the identity of neural progenitor cells and differentially regulating their proliferation.http://www.sciencedirect.com/science/article/pii/S2589004221009007Molecular neuroscienceCell biologyDevelopmental biology |
| spellingShingle | Sayantanee Biswas Michelle R. Emond Kurtis P. Chenoweth James D. Jontes δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling iScience Molecular neuroscience Cell biology Developmental biology |
| title | δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling |
| title_full | δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling |
| title_fullStr | δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling |
| title_full_unstemmed | δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling |
| title_short | δ-Protocadherins regulate neural progenitor cell division by antagonizing Ryk and Wnt/β-catenin signaling |
| title_sort | δ protocadherins regulate neural progenitor cell division by antagonizing ryk and wnt β catenin signaling |
| topic | Molecular neuroscience Cell biology Developmental biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221009007 |
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