Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome
He main issue in osteoporosis management is the duration of treatment with different drugs particularly in cases of severe osteoporosis with high fracture risks and indications of switching from one to other agents. Denosumab is a new class of osteoporosis treatment called a human monoclonal antibod...
| Format: | Article |
|---|---|
| Language: | English |
| Published: |
Endocrinology Research Centre
2013-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/6388 |
| _version_ | 1797204675359932416 |
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| collection | DOAJ |
| description | He main issue in osteoporosis management is the duration of treatment with different drugs particularly in cases of severe osteoporosis with high fracture risks and indications of switching from one to other agents. Denosumab is a new class of osteoporosis treatment called a human monoclonal antibody that prevents RANKL-RANK interaction and thereby inhibits osteoclast formation, demonstrates significant efficacy for vertebral, nonvertebral and hip fracture risk reduction. This case demonstrates multifactorial reasons for osteoporosis development (postmenopausal osteoporosis, primary hyperparathyroidism), as well as the long-term applying of different osteoporosis drugs with various actions mechanisms and different effectiveness. |
| first_indexed | 2024-03-08T09:13:17Z |
| format | Article |
| id | doaj.art-8055b65315d04258b7224974790c23e8 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:39:00Z |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-8055b65315d04258b7224974790c23e82024-04-16T16:16:08ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242013-12-01104323510.14341/omet2013432-356300Generalized osteoporosis of mixed origin with severe compression fractures and pain syndromeHe main issue in osteoporosis management is the duration of treatment with different drugs particularly in cases of severe osteoporosis with high fracture risks and indications of switching from one to other agents. Denosumab is a new class of osteoporosis treatment called a human monoclonal antibody that prevents RANKL-RANK interaction and thereby inhibits osteoclast formation, demonstrates significant efficacy for vertebral, nonvertebral and hip fracture risk reduction. This case demonstrates multifactorial reasons for osteoporosis development (postmenopausal osteoporosis, primary hyperparathyroidism), as well as the long-term applying of different osteoporosis drugs with various actions mechanisms and different effectiveness.https://www.omet-endojournals.ru/jour/article/view/6388ostmenopausal osteoporosisprimary hyperparathyroidismdenosumabcytokine system rank/rankl/opg |
| spellingShingle | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome Ожирение и метаболизм ostmenopausal osteoporosis primary hyperparathyroidism denosumab cytokine system rank/rankl/opg |
| title | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| title_full | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| title_fullStr | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| title_full_unstemmed | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| title_short | Generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| title_sort | generalized osteoporosis of mixed origin with severe compression fractures and pain syndrome |
| topic | ostmenopausal osteoporosis primary hyperparathyroidism denosumab cytokine system rank/rankl/opg |
| url | https://www.omet-endojournals.ru/jour/article/view/6388 |