Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
This study aimed to determine the association between suicidal behavior and <i>T. gondii</i> seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against <i>T. gondii</i> were found in 37 (12.1%) out of 306 individuals with a history of suicidal idea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/6/677 |
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| author | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Agar Ramos-Nevárez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Sandra Margarita Cerrillo-Soto Antonio Sifuentes-Álvarez Gustavo Alexis Alvarado-Félix Carlos Alberto Guido-Arreola Leandro Saenz-Soto |
| author_facet | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Agar Ramos-Nevárez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Sandra Margarita Cerrillo-Soto Antonio Sifuentes-Álvarez Gustavo Alexis Alvarado-Félix Carlos Alberto Guido-Arreola Leandro Saenz-Soto |
| author_sort | Cosme Alvarado-Esquivel |
| collection | DOAJ |
| description | This study aimed to determine the association between suicidal behavior and <i>T. gondii</i> seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against <i>T. gondii</i> were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; <i>p</i> = 0.01). Seropositivity to <i>T. gondii</i> was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; <i>p</i> = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; <i>p</i> = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-<i>T. gondii</i> IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against <i>T. gondii</i> were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; <i>p</i> = 0.06). The seroprevalence of <i>T. gondii</i> infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; <i>p</i> = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; <i>p</i> = 0.008). Our results indicate that <i>T. gondii</i> exposure is associated with suicidal behavior among patients attending primary care clinics. |
| first_indexed | 2024-03-10T10:52:45Z |
| format | Article |
| id | doaj.art-80572e045f9c448cbb888720b590ffea |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T10:52:45Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-80572e045f9c448cbb888720b590ffea2023-11-21T22:07:42ZengMDPI AGPathogens2076-08172021-05-0110667710.3390/pathogens10060677Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care ClinicsCosme Alvarado-Esquivel0Sergio Estrada-Martínez1Agar Ramos-Nevárez2Alma Rosa Pérez-Álamos3Isabel Beristain-García4Ángel Osvaldo Alvarado-Félix5Sandra Margarita Cerrillo-Soto6Antonio Sifuentes-Álvarez7Gustavo Alexis Alvarado-Félix8Carlos Alberto Guido-Arreola9Leandro Saenz-Soto10Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoInstitute for Scientific Research “Dr Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoClínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, Durango 34079, MexicoInstitute for Scientific Research “Dr Roberto Rivera-Damm”, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoFacultad de Enfermería y Obstetricia Juárez University of Durango State, Blvd, Juan Pablo II 512, Durango 34000, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoClínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, Durango 34079, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoBiomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, Durango 34000, MexicoClínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, Durango 34079, MexicoClínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, Durango 34079, MexicoThis study aimed to determine the association between suicidal behavior and <i>T. gondii</i> seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against <i>T. gondii</i> were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; <i>p</i> = 0.01). Seropositivity to <i>T. gondii</i> was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; <i>p</i> = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; <i>p</i> = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-<i>T. gondii</i> IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against <i>T. gondii</i> were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; <i>p</i> = 0.06). The seroprevalence of <i>T. gondii</i> infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; <i>p</i> = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; <i>p</i> = 0.008). Our results indicate that <i>T. gondii</i> exposure is associated with suicidal behavior among patients attending primary care clinics.https://www.mdpi.com/2076-0817/10/6/677suicidal behaviorcross-sectional studyprimary careseroprevalenceepidemiology |
| spellingShingle | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Agar Ramos-Nevárez Alma Rosa Pérez-Álamos Isabel Beristain-García Ángel Osvaldo Alvarado-Félix Sandra Margarita Cerrillo-Soto Antonio Sifuentes-Álvarez Gustavo Alexis Alvarado-Félix Carlos Alberto Guido-Arreola Leandro Saenz-Soto Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics Pathogens suicidal behavior cross-sectional study primary care seroprevalence epidemiology |
| title | Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
| title_full | Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
| title_fullStr | Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
| title_full_unstemmed | Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
| title_short | Association between <i>Toxoplasma gondii</i> Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
| title_sort | association between i toxoplasma gondii i exposure and suicidal behavior in patients attending primary health care clinics |
| topic | suicidal behavior cross-sectional study primary care seroprevalence epidemiology |
| url | https://www.mdpi.com/2076-0817/10/6/677 |
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