CSF oligoclonal IgG bands are not associated with ALS progression and prognosis
IntroductionAmyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explore...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1170360/full |
| _version_ | 1797833199678652416 |
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| author | Veronika Klose Veronika Klose Sarah Jesse Sarah Jesse Jan Lewerenz Jan Kassubek Jan Kassubek Johannes Dorst Johannes Dorst Hayrettin Tumani Hayrettin Tumani Albert C. Ludolph Albert C. Ludolph Albert C. Ludolph Francesco Roselli Francesco Roselli Francesco Roselli |
| author_facet | Veronika Klose Veronika Klose Sarah Jesse Sarah Jesse Jan Lewerenz Jan Kassubek Jan Kassubek Johannes Dorst Johannes Dorst Hayrettin Tumani Hayrettin Tumani Albert C. Ludolph Albert C. Ludolph Albert C. Ludolph Francesco Roselli Francesco Roselli Francesco Roselli |
| author_sort | Veronika Klose |
| collection | DOAJ |
| description | IntroductionAmyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.MethodsIgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively collected in the Register Schabia.ResultsThe prevalence of IgG OCB is comparable in ALS and the four neurological cohorts. When the OCB pattern was considered (highlighting either intrathecal or systemic B-cells activation), no effect of OCB pattern on clinic-demographic parameters and overall. ALS patients with intrathecal IgG synthesis (type 2 and 3) were more likely to display infectious, inflammatory or systemic autoimmune conditions.DiscussionThese data suggest that OCB are not related to ALS pathophysiology but rather are a finding possibly indicative a coincidental infectious or inflammatory comorbidity that merits further investigation. |
| first_indexed | 2024-04-09T14:19:38Z |
| format | Article |
| id | doaj.art-8057869a355a4a4caba3270dfffe3ddd |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T14:19:38Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-8057869a355a4a4caba3270dfffe3ddd2023-05-05T04:29:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-05-011410.3389/fneur.2023.11703601170360CSF oligoclonal IgG bands are not associated with ALS progression and prognosisVeronika Klose0Veronika Klose1Sarah Jesse2Sarah Jesse3Jan Lewerenz4Jan Kassubek5Jan Kassubek6Johannes Dorst7Johannes Dorst8Hayrettin Tumani9Hayrettin Tumani10Albert C. Ludolph11Albert C. Ludolph12Albert C. Ludolph13Francesco Roselli14Francesco Roselli15Francesco Roselli16Department of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyNeurozentrum Ulm, Ulm, GermanyDepartment of Neurology, Ulm University, Ulm, GermanyGerman Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, GermanyNeurozentrum Ulm, Ulm, GermanyIntroductionAmyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.MethodsIgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively collected in the Register Schabia.ResultsThe prevalence of IgG OCB is comparable in ALS and the four neurological cohorts. When the OCB pattern was considered (highlighting either intrathecal or systemic B-cells activation), no effect of OCB pattern on clinic-demographic parameters and overall. ALS patients with intrathecal IgG synthesis (type 2 and 3) were more likely to display infectious, inflammatory or systemic autoimmune conditions.DiscussionThese data suggest that OCB are not related to ALS pathophysiology but rather are a finding possibly indicative a coincidental infectious or inflammatory comorbidity that merits further investigation.https://www.frontiersin.org/articles/10.3389/fneur.2023.1170360/fulloligoclonal bandsintrathecal synthesisage of onsetsurvivalcerebrospinal fluidamyotrophic lateral sclerosis |
| spellingShingle | Veronika Klose Veronika Klose Sarah Jesse Sarah Jesse Jan Lewerenz Jan Kassubek Jan Kassubek Johannes Dorst Johannes Dorst Hayrettin Tumani Hayrettin Tumani Albert C. Ludolph Albert C. Ludolph Albert C. Ludolph Francesco Roselli Francesco Roselli Francesco Roselli CSF oligoclonal IgG bands are not associated with ALS progression and prognosis Frontiers in Neurology oligoclonal bands intrathecal synthesis age of onset survival cerebrospinal fluid amyotrophic lateral sclerosis |
| title | CSF oligoclonal IgG bands are not associated with ALS progression and prognosis |
| title_full | CSF oligoclonal IgG bands are not associated with ALS progression and prognosis |
| title_fullStr | CSF oligoclonal IgG bands are not associated with ALS progression and prognosis |
| title_full_unstemmed | CSF oligoclonal IgG bands are not associated with ALS progression and prognosis |
| title_short | CSF oligoclonal IgG bands are not associated with ALS progression and prognosis |
| title_sort | csf oligoclonal igg bands are not associated with als progression and prognosis |
| topic | oligoclonal bands intrathecal synthesis age of onset survival cerebrospinal fluid amyotrophic lateral sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1170360/full |
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