Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study
BackgroundThe non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.MethodsWe performed a...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1323942/full |
| _version_ | 1827578406963773440 |
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| author | Zhuo-Yuan Liang Zhuo-Yuan Liang Zhi-Hao Lu Zhi-Hao Lu Jian-Feng Qu Jian-Feng Qu Yang-Kun Chen Yang-Kun Chen |
| author_facet | Zhuo-Yuan Liang Zhuo-Yuan Liang Zhi-Hao Lu Zhi-Hao Lu Jian-Feng Qu Jian-Feng Qu Yang-Kun Chen Yang-Kun Chen |
| author_sort | Zhuo-Yuan Liang |
| collection | DOAJ |
| description | BackgroundThe non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.MethodsWe performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.ResultsEleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, P<0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates <60 ml/min/1.73m2) (55% vs. 20%, P=0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.ConclusionA higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC. |
| first_indexed | 2024-03-08T21:46:07Z |
| format | Article |
| id | doaj.art-8057d4d87c2644c9994cd4b74117e343 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T21:46:07Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8057d4d87c2644c9994cd4b74117e3432023-12-20T09:03:55ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13239421323942Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control studyZhuo-Yuan Liang0Zhuo-Yuan Liang1Zhi-Hao Lu2Zhi-Hao Lu3Jian-Feng Qu4Jian-Feng Qu5Yang-Kun Chen6Yang-Kun Chen7Department of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong, ChinaIntelligent Brain Imaging and Brain Function Laboratory (Dongguan Key Laboratory), Dongguan People’s Hospital, Dongguan, Guangdong, ChinaDepartment of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong, ChinaIntelligent Brain Imaging and Brain Function Laboratory (Dongguan Key Laboratory), Dongguan People’s Hospital, Dongguan, Guangdong, ChinaDepartment of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong, ChinaIntelligent Brain Imaging and Brain Function Laboratory (Dongguan Key Laboratory), Dongguan People’s Hospital, Dongguan, Guangdong, ChinaDepartment of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong, ChinaIntelligent Brain Imaging and Brain Function Laboratory (Dongguan Key Laboratory), Dongguan People’s Hospital, Dongguan, Guangdong, ChinaBackgroundThe non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.MethodsWe performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.ResultsEleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, P<0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates <60 ml/min/1.73m2) (55% vs. 20%, P=0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.ConclusionA higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC.https://www.frontiersin.org/articles/10.3389/fendo.2023.1323942/fullnon-ketotic hyperglycemic choreadiabetes mellituscase-control studyrenal dysfunctionassociation |
| spellingShingle | Zhuo-Yuan Liang Zhuo-Yuan Liang Zhi-Hao Lu Zhi-Hao Lu Jian-Feng Qu Jian-Feng Qu Yang-Kun Chen Yang-Kun Chen Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study Frontiers in Endocrinology non-ketotic hyperglycemic chorea diabetes mellitus case-control study renal dysfunction association |
| title | Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study |
| title_full | Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study |
| title_fullStr | Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study |
| title_full_unstemmed | Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study |
| title_short | Clinical and imaging associations for non-ketotic hyperglycemic chorea: a case-control study |
| title_sort | clinical and imaging associations for non ketotic hyperglycemic chorea a case control study |
| topic | non-ketotic hyperglycemic chorea diabetes mellitus case-control study renal dysfunction association |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1323942/full |
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