Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis

Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis

Abstract Objective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This study aimed to investigate the role of endoplasmic reticulum aminopeptid...

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Bibliographic Details
Main Authors: Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu, Youhua Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Arthritis Research & Therapy
Subjects:
Pyroptosis
CD4+ T cells
ERAP2
Rheumatoid arthritis
Hedgehog signaling pathway
Online Access:https://doi.org/10.1186/s13075-024-03271-3

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