Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database
Jean-Pierre Llanos,1 Hector Ortega,2 Guillaume Germain,3 Mei Sheng Duh,4 Marie-Helene Lafeuille,3 Sean Tiggelaar,3 Christopher F Bell1, Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2US Medical Affairs, GSK, La Jolla, CA, USA; 3Groupe d’Analyse, Ltée, Mo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-09-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/health-characteristics-of-patients-with-asthma-copd-and-asthma-copd-ov-peer-reviewed-article-COPD |
| _version_ | 1819145935488286720 |
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| author | Llanos JP Ortega H Germain G Duh MS Lafeuille MH Tiggelaar S Bell CF Hahn B |
| author_facet | Llanos JP Ortega H Germain G Duh MS Lafeuille MH Tiggelaar S Bell CF Hahn B |
| author_sort | Llanos JP |
| collection | DOAJ |
| description | Jean-Pierre Llanos,1 Hector Ortega,2 Guillaume Germain,3 Mei Sheng Duh,4 Marie-Helene Lafeuille,3 Sean Tiggelaar,3 Christopher F Bell1, Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2US Medical Affairs, GSK, La Jolla, CA, USA; 3Groupe d’Analyse, Ltée, Montréal, QC, Canada; 4Analysis Group, Inc., Boston, MA, USA Introduction: Asthma and COPD have overlapping characteristics. As there are limited data on whether asthma–COPD overlap (ACO) represents a distinct condition, this study aimed to determine the similarities and differences of ACO with asthma and COPD.Methods: US population-based, cross-sectional study using National Health and Nutrition Examination Survey data (2009–2012) compared participants with ACO vs those with asthma or COPD, each as mutually exclusive disease states. Demographics, health status, disability/limitations, health care resource utilization, clinical characteristics, and peripheral blood eosinophil counts were analyzed.Results: A total of 1,609, 479, and 299 participants with asthma, COPD, and ACO, respectively, were included. An age-matched asthma subgroup included 299 participants from the asthma group. Compared with asthma and COPD, participants with ACO had worse health status, increased disease burden, and more comorbid conditions. The ACO, vs age-matched asthma subgroup, had lower percent predicted prebronchodilator forced expiratory volume in 1 second (82.1% vs 88.0%; P=0.017). The ACO group had significantly more asthma attacks in the past year than the age-matched asthma subgroup (49.8% vs 38.4%; P<0.001). The ACO group had more participants with postbronchodilator forced expiratory volume in 1 second <80% predicted (52.1%) vs COPD (30.8%; P=0.003) and more participants with blood eosinophil counts ≥400 cells/µL (16.9%) vs COPD (9.5%; P=0.007) and the asthma subgroup (6.7%; P=0.014).Conclusion: The ACO group represents an important subset of patients with chronic respiratory disease with an increased burden of disease over asthma and COPD individually. Early identification of this population will enable appropriate therapeutic interventions in a timely manner. Keywords: lung function, health status, eosinophils, asthma attack, respiratory disease |
| first_indexed | 2024-12-22T13:05:56Z |
| format | Article |
| id | doaj.art-8058e2923b354e268461dcd75151c4a8 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-22T13:05:56Z |
| publishDate | 2018-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-8058e2923b354e268461dcd75151c4a82022-12-21T18:24:53ZengDove Medical PressInternational Journal of COPD1178-20052018-09-01Volume 132859286840577Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES databaseLlanos JPOrtega HGermain GDuh MSLafeuille MHTiggelaar SBell CFHahn BJean-Pierre Llanos,1 Hector Ortega,2 Guillaume Germain,3 Mei Sheng Duh,4 Marie-Helene Lafeuille,3 Sean Tiggelaar,3 Christopher F Bell1, Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2US Medical Affairs, GSK, La Jolla, CA, USA; 3Groupe d’Analyse, Ltée, Montréal, QC, Canada; 4Analysis Group, Inc., Boston, MA, USA Introduction: Asthma and COPD have overlapping characteristics. As there are limited data on whether asthma–COPD overlap (ACO) represents a distinct condition, this study aimed to determine the similarities and differences of ACO with asthma and COPD.Methods: US population-based, cross-sectional study using National Health and Nutrition Examination Survey data (2009–2012) compared participants with ACO vs those with asthma or COPD, each as mutually exclusive disease states. Demographics, health status, disability/limitations, health care resource utilization, clinical characteristics, and peripheral blood eosinophil counts were analyzed.Results: A total of 1,609, 479, and 299 participants with asthma, COPD, and ACO, respectively, were included. An age-matched asthma subgroup included 299 participants from the asthma group. Compared with asthma and COPD, participants with ACO had worse health status, increased disease burden, and more comorbid conditions. The ACO, vs age-matched asthma subgroup, had lower percent predicted prebronchodilator forced expiratory volume in 1 second (82.1% vs 88.0%; P=0.017). The ACO group had significantly more asthma attacks in the past year than the age-matched asthma subgroup (49.8% vs 38.4%; P<0.001). The ACO group had more participants with postbronchodilator forced expiratory volume in 1 second <80% predicted (52.1%) vs COPD (30.8%; P=0.003) and more participants with blood eosinophil counts ≥400 cells/µL (16.9%) vs COPD (9.5%; P=0.007) and the asthma subgroup (6.7%; P=0.014).Conclusion: The ACO group represents an important subset of patients with chronic respiratory disease with an increased burden of disease over asthma and COPD individually. Early identification of this population will enable appropriate therapeutic interventions in a timely manner. Keywords: lung function, health status, eosinophils, asthma attack, respiratory diseasehttps://www.dovepress.com/health-characteristics-of-patients-with-asthma-copd-and-asthma-copd-ov-peer-reviewed-article-COPDlung functionhealth statuseosinophilsasthma attackrespiratory disease |
| spellingShingle | Llanos JP Ortega H Germain G Duh MS Lafeuille MH Tiggelaar S Bell CF Hahn B Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database International Journal of COPD lung function health status eosinophils asthma attack respiratory disease |
| title | Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database |
| title_full | Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database |
| title_fullStr | Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database |
| title_full_unstemmed | Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database |
| title_short | Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database |
| title_sort | health characteristics of patients with asthma copd and asthma ndash copd overlap in the nhanes database |
| topic | lung function health status eosinophils asthma attack respiratory disease |
| url | https://www.dovepress.com/health-characteristics-of-patients-with-asthma-copd-and-asthma-copd-ov-peer-reviewed-article-COPD |
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