Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry
The risk of bleeding as predicted by the PRECISE-DAPT score can vary over time after percutaneous coronary intervention (PCI). We sought to compare the predictive ability of the PRECISE-DAPT score calculated at baseline and reassessed during follow-up in male and female patients undergoing PCI. The...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-11-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2022.2102602 |
| _version_ | 1797684146352422912 |
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| author | Francesco Pelliccia Felice Gragnano Vincenzo Pasceri Giuseppe Marazzi Luca Cacciotti Attilio Placanica Giampaolo Niccoli Tullio Palmerini Giulio Speciale Antonino Granatelli Paolo Calabrò |
| author_facet | Francesco Pelliccia Felice Gragnano Vincenzo Pasceri Giuseppe Marazzi Luca Cacciotti Attilio Placanica Giampaolo Niccoli Tullio Palmerini Giulio Speciale Antonino Granatelli Paolo Calabrò |
| author_sort | Francesco Pelliccia |
| collection | DOAJ |
| description | The risk of bleeding as predicted by the PRECISE-DAPT score can vary over time after percutaneous coronary intervention (PCI). We sought to compare the predictive ability of the PRECISE-DAPT score calculated at baseline and reassessed during follow-up in male and female patients undergoing PCI. The RE-SCORE was a multicenter, prospective registry including patients undergoing PCI treated with dual antiplatelet therapy (DAPT) for 1 year. The primary endpoint was Bleeding Academic Research Consortium (BARC) type 2, 3 or 5 bleeding. The PRECISE-DAPT score was determined for each patient at the time of PCI and at 1, 4 and 8-month follow-up visits or before the occurrence of an endpoint event. A total of 480 patients undergoing PCI were included. At baseline, median PRECISE-DAPT score was similar in males (23.2 [IQR 20.1–24.2]) and females (23.4 [IQR 20.2–25.3]; p = .22). During follow-up, an increase in the PRECISE-DAPT occurred significantly more often in females (44%) than in males (23%; p < .001). The discrimination of the PRECISE-DAPT score calculated at baseline was marginal in both males (c-index = 0.59, 95% CI: 0.51–0.65) and females (c-index = 0.55, 95% CI: 0.49–0.60). The discriminative ability of the score reassessed at follow-up was excellent in females (c-index = 0.84; 95% CI: 0.77–0.91) but remained modest in males (c-index = 0.61; 95% CI: 0.55–0.70). The bleeding predictive ability of the PRECISE-DAPT score can vary over time, more commonly in females than males. The discrimination of the score calculated during follow-up appeared improved in females but remained modest in males. Clinical Trial Registration - ClinicalTrials.gov Identifier: NCT03526614 |
| first_indexed | 2024-03-12T00:25:16Z |
| format | Article |
| id | doaj.art-8059fb6e35ad4afcad598fa6cf241bb7 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:16Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-8059fb6e35ad4afcad598fa6cf241bb72023-09-15T10:38:11ZengTaylor & Francis GroupPlatelets0953-71041369-16352022-11-013381228123610.1080/09537104.2022.21026022102602Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registryFrancesco Pelliccia0Felice Gragnano1Vincenzo Pasceri2Giuseppe Marazzi3Luca Cacciotti4Attilio Placanica5Giampaolo Niccoli6Tullio Palmerini7Giulio Speciale8Antonino Granatelli9Paolo Calabrò10Sapienza UniversityA.O.R.N. ‘Sant’Anna e San Sebastiano’San Filippo Neri HospitalSan RaffaeleOspedale VanniniOspedale di TivoliUniversity of ParmaPolo Cardio-Toraco Vascolare, Policlinico S. OrsolaSan Filippo Neri HospitalOspedale di TivoliA.O.R.N. ‘Sant’Anna e San Sebastiano’The risk of bleeding as predicted by the PRECISE-DAPT score can vary over time after percutaneous coronary intervention (PCI). We sought to compare the predictive ability of the PRECISE-DAPT score calculated at baseline and reassessed during follow-up in male and female patients undergoing PCI. The RE-SCORE was a multicenter, prospective registry including patients undergoing PCI treated with dual antiplatelet therapy (DAPT) for 1 year. The primary endpoint was Bleeding Academic Research Consortium (BARC) type 2, 3 or 5 bleeding. The PRECISE-DAPT score was determined for each patient at the time of PCI and at 1, 4 and 8-month follow-up visits or before the occurrence of an endpoint event. A total of 480 patients undergoing PCI were included. At baseline, median PRECISE-DAPT score was similar in males (23.2 [IQR 20.1–24.2]) and females (23.4 [IQR 20.2–25.3]; p = .22). During follow-up, an increase in the PRECISE-DAPT occurred significantly more often in females (44%) than in males (23%; p < .001). The discrimination of the PRECISE-DAPT score calculated at baseline was marginal in both males (c-index = 0.59, 95% CI: 0.51–0.65) and females (c-index = 0.55, 95% CI: 0.49–0.60). The discriminative ability of the score reassessed at follow-up was excellent in females (c-index = 0.84; 95% CI: 0.77–0.91) but remained modest in males (c-index = 0.61; 95% CI: 0.55–0.70). The bleeding predictive ability of the PRECISE-DAPT score can vary over time, more commonly in females than males. The discrimination of the score calculated during follow-up appeared improved in females but remained modest in males. Clinical Trial Registration - ClinicalTrials.gov Identifier: NCT03526614http://dx.doi.org/10.1080/09537104.2022.2102602bleedingdual antiplatelet therapypercutaneous coronary intervention |
| spellingShingle | Francesco Pelliccia Felice Gragnano Vincenzo Pasceri Giuseppe Marazzi Luca Cacciotti Attilio Placanica Giampaolo Niccoli Tullio Palmerini Giulio Speciale Antonino Granatelli Paolo Calabrò Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry Platelets bleeding dual antiplatelet therapy percutaneous coronary intervention |
| title | Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry |
| title_full | Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry |
| title_fullStr | Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry |
| title_full_unstemmed | Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry |
| title_short | Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry |
| title_sort | gender related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy the re score multicenter prospective registry |
| topic | bleeding dual antiplatelet therapy percutaneous coronary intervention |
| url | http://dx.doi.org/10.1080/09537104.2022.2102602 |
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