Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury
Abstract Background A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administration at the time of cardiac ischemia/reperfusion (I/R) injury are not e...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-020-01066-9 |
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| author | Sarayut Lahnwong Siripong Palee Nattayaporn Apaijai Sirawit Sriwichaiin Sasiwan Kerdphoo Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn |
| author_facet | Sarayut Lahnwong Siripong Palee Nattayaporn Apaijai Sirawit Sriwichaiin Sasiwan Kerdphoo Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn |
| author_sort | Sarayut Lahnwong |
| collection | DOAJ |
| description | Abstract Background A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administration at the time of cardiac ischemia/reperfusion (I/R) injury are not established. Methods The effects of dapagliflozin on cardiac function were investigated by treating cardiac I/R injury at different time points. Cardiac I/R was instigated in forty-eight Wistar rats. These rats were then split into 4 interventional groups: control, dapagliflozin (SGLT2 inhibitor, 1 mg/kg) given pre-ischemia, at the time of ischemia and at the beginning of reperfusion. Left ventricular (LV) function and arrhythmia score were evaluated. The hearts were used to evaluate size of myocardial infarction, cardiomyocyte apoptosis, cardiac mitochondrial dynamics and function. Results Dapagliflozin given pre-ischemia conferred the maximum level of cardioprotection quantified through the decrease in arrhythmia, attenuated infarct size, decreased cardiac apoptosis and improved cardiac mitochondrial function, biogenesis and dynamics, leading to LV function improvement during cardiac I/R injury. Dapagliflozin given during ischemia also showed cardioprotection, but at a lower level of efficacy. Conclusions Acute dapagliflozin administration during cardiac I/R injury exerted cardioprotective effects by attenuating cardiac infarct size, increasing LV function and reducing arrhythmias. These benefits indicate its potential clinical usefulness. |
| first_indexed | 2024-12-13T12:11:45Z |
| format | Article |
| id | doaj.art-805adb75e5124b9ba01efa704d3571aa |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-13T12:11:45Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-805adb75e5124b9ba01efa704d3571aa2022-12-21T23:46:49ZengBMCCardiovascular Diabetology1475-28402020-06-0119111310.1186/s12933-020-01066-9Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injurySarayut Lahnwong0Siripong Palee1Nattayaporn Apaijai2Sirawit Sriwichaiin3Sasiwan Kerdphoo4Thidarat Jaiwongkam5Siriporn C. Chattipakorn6Nipon Chattipakorn7Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityCardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai UniversityAbstract Background A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with the severity of heart failure. However, the effects of acute dapagliflozin administration at the time of cardiac ischemia/reperfusion (I/R) injury are not established. Methods The effects of dapagliflozin on cardiac function were investigated by treating cardiac I/R injury at different time points. Cardiac I/R was instigated in forty-eight Wistar rats. These rats were then split into 4 interventional groups: control, dapagliflozin (SGLT2 inhibitor, 1 mg/kg) given pre-ischemia, at the time of ischemia and at the beginning of reperfusion. Left ventricular (LV) function and arrhythmia score were evaluated. The hearts were used to evaluate size of myocardial infarction, cardiomyocyte apoptosis, cardiac mitochondrial dynamics and function. Results Dapagliflozin given pre-ischemia conferred the maximum level of cardioprotection quantified through the decrease in arrhythmia, attenuated infarct size, decreased cardiac apoptosis and improved cardiac mitochondrial function, biogenesis and dynamics, leading to LV function improvement during cardiac I/R injury. Dapagliflozin given during ischemia also showed cardioprotection, but at a lower level of efficacy. Conclusions Acute dapagliflozin administration during cardiac I/R injury exerted cardioprotective effects by attenuating cardiac infarct size, increasing LV function and reducing arrhythmias. These benefits indicate its potential clinical usefulness.http://link.springer.com/article/10.1186/s12933-020-01066-9HeartIschemia–reperfusion injurySodium-glucose co-transporter 2 (SGLT-2) inhibitorsDapagliflozinMitochondria |
| spellingShingle | Sarayut Lahnwong Siripong Palee Nattayaporn Apaijai Sirawit Sriwichaiin Sasiwan Kerdphoo Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury Cardiovascular Diabetology Heart Ischemia–reperfusion injury Sodium-glucose co-transporter 2 (SGLT-2) inhibitors Dapagliflozin Mitochondria |
| title | Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury |
| title_full | Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury |
| title_fullStr | Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury |
| title_full_unstemmed | Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury |
| title_short | Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury |
| title_sort | acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia reperfusion injury |
| topic | Heart Ischemia–reperfusion injury Sodium-glucose co-transporter 2 (SGLT-2) inhibitors Dapagliflozin Mitochondria |
| url | http://link.springer.com/article/10.1186/s12933-020-01066-9 |
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