Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults
The incidence of nonalcoholic fatty liver disease (NAFLD) is highest among Mexican‐origin (MO) adults. Few studies have estimated the prevalence of NAFLD in this subpopulation, particularly by sex and age. We assessed the prevalence of NAFLD in a community sample of MO adults residing in a border re...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2022-06-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1896 |
| _version_ | 1797756851587121152 |
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| author | David O. Garcia Kristin E. Morrill Melissa Lopez‐Pentecost Edgar A. Villavicencio Rosa M. Vogel Melanie L. Bell Yann C. Klimentidis David G. Marrero Cynthia A. Thomson |
| author_facet | David O. Garcia Kristin E. Morrill Melissa Lopez‐Pentecost Edgar A. Villavicencio Rosa M. Vogel Melanie L. Bell Yann C. Klimentidis David G. Marrero Cynthia A. Thomson |
| author_sort | David O. Garcia |
| collection | DOAJ |
| description | The incidence of nonalcoholic fatty liver disease (NAFLD) is highest among Mexican‐origin (MO) adults. Few studies have estimated the prevalence of NAFLD in this subpopulation, particularly by sex and age. We assessed the prevalence of NAFLD in a community sample of MO adults residing in a border region of southern Arizona and determined risk factors associated with NAFLD. A total of 307 MO adults (n = 194 women; n = 113 men) with overweight or obesity completed an in‐person study visit, including vibration‐controlled transient elastography (FibroScan) for the assessment of NAFLD status. A continuous attenuation parameter score of ≥288 dB/m (≥5% hepatic steatosis) indicated NAFLD status. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD. We identified 155 participants (50%) with NAFLD, including 52% of women and 48% of men; there were no sex differences in steatosis (men, 287.8 dB/m; women, 288.4 dB/m). Sex, age, patatin‐like phospholipase domain containing 3 (PNPLA3) risk allele carrier status, comorbidities, and cultural and behavioral variables were not associated with NAFLD status. There was some evidence for effect modification of body mass index (BMI) by sex (Pinteraction = 0.08). The estimated OR for an increase in BMI of 5 kg/m2 was 3.36 (95% CI, 1.90, 5.91) for men and 1.92 (95% CI, 1.40, 2.64) for women. In post hoc analyses treating steatosis as a continuous variable in a linear regression, significant effect modification was found for BMI by sex (Pinteraction = 0.03), age (P = 0.05), and PNPLA3 risk allele carrier status (P = 0.02). Conclusion: Lifestyle interventions to reduce body weight, with consideration of age and genetic risk status, are needed to stem the higher rates of NAFLD observed for MO populations. |
| first_indexed | 2024-03-12T18:07:31Z |
| format | Article |
| id | doaj.art-805bc6c10e1341bdafbfd9ee3940d94b |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-03-12T18:07:31Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-805bc6c10e1341bdafbfd9ee3940d94b2023-08-02T09:26:02ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2022-06-01661322133510.1002/hep4.1896Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin AdultsDavid O. Garcia0Kristin E. Morrill1Melissa Lopez‐Pentecost2Edgar A. Villavicencio3Rosa M. Vogel4Melanie L. Bell5Yann C. Klimentidis6David G. Marrero7Cynthia A. Thomson8Department of Health Promotion Sciences University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USAUniversity of Arizona Cancer Center Tucson AZ USAClinical Translational Sciences College of Medicine University of Arizona Tucson AZ USADepartment of Health Promotion Sciences University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USADepartment of Health Promotion Sciences University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USADepartment of Epidemiology and Biostatistics University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USADepartment of Epidemiology and Biostatistics University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USADepartment of Health Promotion Sciences University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USADepartment of Health Promotion Sciences University of ArizonaMel and Enid Zuckerman College of Public Health Tucson AZ USAThe incidence of nonalcoholic fatty liver disease (NAFLD) is highest among Mexican‐origin (MO) adults. Few studies have estimated the prevalence of NAFLD in this subpopulation, particularly by sex and age. We assessed the prevalence of NAFLD in a community sample of MO adults residing in a border region of southern Arizona and determined risk factors associated with NAFLD. A total of 307 MO adults (n = 194 women; n = 113 men) with overweight or obesity completed an in‐person study visit, including vibration‐controlled transient elastography (FibroScan) for the assessment of NAFLD status. A continuous attenuation parameter score of ≥288 dB/m (≥5% hepatic steatosis) indicated NAFLD status. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD. We identified 155 participants (50%) with NAFLD, including 52% of women and 48% of men; there were no sex differences in steatosis (men, 287.8 dB/m; women, 288.4 dB/m). Sex, age, patatin‐like phospholipase domain containing 3 (PNPLA3) risk allele carrier status, comorbidities, and cultural and behavioral variables were not associated with NAFLD status. There was some evidence for effect modification of body mass index (BMI) by sex (Pinteraction = 0.08). The estimated OR for an increase in BMI of 5 kg/m2 was 3.36 (95% CI, 1.90, 5.91) for men and 1.92 (95% CI, 1.40, 2.64) for women. In post hoc analyses treating steatosis as a continuous variable in a linear regression, significant effect modification was found for BMI by sex (Pinteraction = 0.03), age (P = 0.05), and PNPLA3 risk allele carrier status (P = 0.02). Conclusion: Lifestyle interventions to reduce body weight, with consideration of age and genetic risk status, are needed to stem the higher rates of NAFLD observed for MO populations.https://doi.org/10.1002/hep4.1896 |
| spellingShingle | David O. Garcia Kristin E. Morrill Melissa Lopez‐Pentecost Edgar A. Villavicencio Rosa M. Vogel Melanie L. Bell Yann C. Klimentidis David G. Marrero Cynthia A. Thomson Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults Hepatology Communications |
| title | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults |
| title_full | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults |
| title_fullStr | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults |
| title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults |
| title_short | Nonalcoholic Fatty Liver Disease and Associated Risk Factors in a Community‐Based Sample of Mexican‐Origin Adults |
| title_sort | nonalcoholic fatty liver disease and associated risk factors in a community based sample of mexican origin adults |
| url | https://doi.org/10.1002/hep4.1896 |
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