Genetic Architecture of Transcription and Chromatin Regulation
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korea Genome Organization
2015-06-01
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| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-13-40.pdf |
| _version_ | 1818520727333109760 |
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| author | Kwoneel Kim Hyoeun Bang Kibaick Lee Jung Kyoon Choi |
| author_facet | Kwoneel Kim Hyoeun Bang Kibaick Lee Jung Kyoon Choi |
| author_sort | Kwoneel Kim |
| collection | DOAJ |
| description | DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation. |
| first_indexed | 2024-12-11T01:41:28Z |
| format | Article |
| id | doaj.art-805bd598494847efbcc3da4e8f18da97 |
| institution | Directory Open Access Journal |
| issn | 1598-866X 2234-0742 |
| language | English |
| last_indexed | 2024-12-11T01:41:28Z |
| publishDate | 2015-06-01 |
| publisher | Korea Genome Organization |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj.art-805bd598494847efbcc3da4e8f18da972022-12-22T01:25:01ZengKorea Genome OrganizationGenomics & Informatics1598-866X2234-07422015-06-01132404410.5808/GI.2015.13.2.40148Genetic Architecture of Transcription and Chromatin RegulationKwoneel Kim0Hyoeun Bang1Kibaick Lee2Jung Kyoon Choi3Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.http://genominfo.org/upload/pdf/gni-13-40.pdfepigenetic processgene expressionquantitative trait lociregulatory regions |
| spellingShingle | Kwoneel Kim Hyoeun Bang Kibaick Lee Jung Kyoon Choi Genetic Architecture of Transcription and Chromatin Regulation Genomics & Informatics epigenetic process gene expression quantitative trait loci regulatory regions |
| title | Genetic Architecture of Transcription and Chromatin Regulation |
| title_full | Genetic Architecture of Transcription and Chromatin Regulation |
| title_fullStr | Genetic Architecture of Transcription and Chromatin Regulation |
| title_full_unstemmed | Genetic Architecture of Transcription and Chromatin Regulation |
| title_short | Genetic Architecture of Transcription and Chromatin Regulation |
| title_sort | genetic architecture of transcription and chromatin regulation |
| topic | epigenetic process gene expression quantitative trait loci regulatory regions |
| url | http://genominfo.org/upload/pdf/gni-13-40.pdf |
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