BF066, a novel dual target antiplatelet agent without significant bleeding.

BF066, a novel dual target antiplatelet agent without significant bleeding.

In this study, we report BF066, a novel adenine derivative, inhibits platelet activation and thrombosis via the adenosine receptor (A(2A)) activation and phosphodiesterase (PDE) inhibition. BF066 inhibits platelet aggregation and ATP releasing induced by multiple platelet agonists in a dose-dependen...

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Bibliographic Details
Main Authors: ChangE Pan, Xunbin Wei, Jianqin Ye, Guangda Liu, Si Zhang, Yan Zhang, Hongguang Du, Zhongren Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3398006?pdf=render

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