Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues
In the present investigation we report herein the synthesis and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4a–c). The anticonvulsant activity and neuroprotection assay were done according to Antiepileptic Drug Development Programm...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-05-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535213003638 |
| _version_ | 1818445601632681984 |
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| author | Mohamed Jawed Ahsan |
| author_facet | Mohamed Jawed Ahsan |
| author_sort | Mohamed Jawed Ahsan |
| collection | DOAJ |
| description | In the present investigation we report herein the synthesis and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4a–c). The anticonvulsant activity and neuroprotection assay were done according to Antiepileptic Drug Development Programme (ADD) protocol reported elsewhere. The compounds showed significant anticonvulsant and neuroprotective activities. The compound 4b showed neuroprotection activity with 26.2 ± 1.9% of total propidium iodide uptake at 100 μM and IC50 of the compound was calculated using dose response curve by probit analysis and was found to be 159.20 ± 1.21 μM. |
| first_indexed | 2024-12-14T19:34:26Z |
| format | Article |
| id | doaj.art-805da60b4bb340c2b1a3c56df63a00a3 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-14T19:34:26Z |
| publishDate | 2017-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-805da60b4bb340c2b1a3c56df63a00a32022-12-21T22:49:56ZengElsevierArabian Journal of Chemistry1878-53522017-05-0110S2S2762S276610.1016/j.arabjc.2013.10.023Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analoguesMohamed Jawed AhsanIn the present investigation we report herein the synthesis and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4a–c). The anticonvulsant activity and neuroprotection assay were done according to Antiepileptic Drug Development Programme (ADD) protocol reported elsewhere. The compounds showed significant anticonvulsant and neuroprotective activities. The compound 4b showed neuroprotection activity with 26.2 ± 1.9% of total propidium iodide uptake at 100 μM and IC50 of the compound was calculated using dose response curve by probit analysis and was found to be 159.20 ± 1.21 μM.http://www.sciencedirect.com/science/article/pii/S1878535213003638Anticonvulsant agentNeuroprotection assayPyrazoline |
| spellingShingle | Mohamed Jawed Ahsan Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues Arabian Journal of Chemistry Anticonvulsant agent Neuroprotection assay Pyrazoline |
| title | Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues |
| title_full | Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues |
| title_fullStr | Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues |
| title_full_unstemmed | Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues |
| title_short | Anticonvulsant activity and neuroprotection assay of 3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide analogues |
| title_sort | anticonvulsant activity and neuroprotection assay of 3 substituted n aryl 6 7 dimethoxy 3a 4 dihydro 3h indeno 1 2 c pyrazole 2 carboxamide analogues |
| topic | Anticonvulsant agent Neuroprotection assay Pyrazoline |
| url | http://www.sciencedirect.com/science/article/pii/S1878535213003638 |
| work_keys_str_mv | AT mohamedjawedahsan anticonvulsantactivityandneuroprotectionassayof3substitutednaryl67dimethoxy3a4dihydro3hindeno12cpyrazole2carboxamideanalogues |