Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review
<b>Background:</b> This systematic review aimed to evaluate the impact of antiresorptive drug therapy on osseointegrated dental implants and the association with medication-related osteonecrosis of the jaw (MRONJ). <b>Methods:</b> A systematic search, including a computer sea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/2091 |
| _version_ | 1797212370367414272 |
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| author | Joyce Tin Wing Li Yiu Yan Leung |
| author_facet | Joyce Tin Wing Li Yiu Yan Leung |
| author_sort | Joyce Tin Wing Li |
| collection | DOAJ |
| description | <b>Background:</b> This systematic review aimed to evaluate the impact of antiresorptive drug therapy on osseointegrated dental implants and the association with medication-related osteonecrosis of the jaw (MRONJ). <b>Methods:</b> A systematic search, including a computer search of several databases with specific keywords, a reference search, and a manual search of four key maxillofacial journals were performed. Relevant articles were then evaluated and those that fulfilled the five predetermined criteria were chosen to enter the final review. A total of 445 implants in 135 subjects were included in the eight studies analyzed in the final review. <b>Results:</b> The failure rate of dental implants after antiresorptive medication in the included studies was 23%, with 83% of failures attributed to MRONJ. The average time from antiresorptive drug initiation to MRONJ development was approximately 34 months, ranging from 3 months to 16 years. The majority of MRONJ cases were classified as stage 2, and all sites showed either complete healing or substantial mucosal coverage after treatment. <b>Conclusions:</b> This review highlights the significant impact of antiresorptive drugs on osseo- integrated implants, with MRONJ identified as a leading cause of implant failure. The potential role of peri-implantitis as a trigger for MRONJ is emphasized. Regular monitoring and maintaining good periodontal health, especially within the first three years of antiresorptive drug therapy initiation, are crucial for implant success. Physicians and dentists should provide comprehensive information to patients prescribed with antiresorptive drugs, emphasizing the need for an awareness of the risks of MRONJ in the context of osseointegrated implants. A longer term of follow-up is recommended to identify and manage MRONJ around dental implants in an early manner. |
| first_indexed | 2024-04-24T10:41:18Z |
| format | Article |
| id | doaj.art-805f956e70774cde80c4ba292b31007a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:41:18Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-805f956e70774cde80c4ba292b31007a2024-04-12T13:21:31ZengMDPI AGJournal of Clinical Medicine2077-03832024-04-01137209110.3390/jcm13072091Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic ReviewJoyce Tin Wing Li0Yiu Yan Leung1Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong KongOral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong<b>Background:</b> This systematic review aimed to evaluate the impact of antiresorptive drug therapy on osseointegrated dental implants and the association with medication-related osteonecrosis of the jaw (MRONJ). <b>Methods:</b> A systematic search, including a computer search of several databases with specific keywords, a reference search, and a manual search of four key maxillofacial journals were performed. Relevant articles were then evaluated and those that fulfilled the five predetermined criteria were chosen to enter the final review. A total of 445 implants in 135 subjects were included in the eight studies analyzed in the final review. <b>Results:</b> The failure rate of dental implants after antiresorptive medication in the included studies was 23%, with 83% of failures attributed to MRONJ. The average time from antiresorptive drug initiation to MRONJ development was approximately 34 months, ranging from 3 months to 16 years. The majority of MRONJ cases were classified as stage 2, and all sites showed either complete healing or substantial mucosal coverage after treatment. <b>Conclusions:</b> This review highlights the significant impact of antiresorptive drugs on osseo- integrated implants, with MRONJ identified as a leading cause of implant failure. The potential role of peri-implantitis as a trigger for MRONJ is emphasized. Regular monitoring and maintaining good periodontal health, especially within the first three years of antiresorptive drug therapy initiation, are crucial for implant success. Physicians and dentists should provide comprehensive information to patients prescribed with antiresorptive drugs, emphasizing the need for an awareness of the risks of MRONJ in the context of osseointegrated implants. A longer term of follow-up is recommended to identify and manage MRONJ around dental implants in an early manner.https://www.mdpi.com/2077-0383/13/7/2091dental implantosseointegrationantiresorptive drugbisphosphonatedenosumabmedication-related osteonecrosis of the jaw |
| spellingShingle | Joyce Tin Wing Li Yiu Yan Leung Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review Journal of Clinical Medicine dental implant osseointegration antiresorptive drug bisphosphonate denosumab medication-related osteonecrosis of the jaw |
| title | Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review |
| title_full | Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review |
| title_fullStr | Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review |
| title_full_unstemmed | Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review |
| title_short | Effect of Antiresorptive Drugs on Osseointegrated Dental Implants: A Systematic Review |
| title_sort | effect of antiresorptive drugs on osseointegrated dental implants a systematic review |
| topic | dental implant osseointegration antiresorptive drug bisphosphonate denosumab medication-related osteonecrosis of the jaw |
| url | https://www.mdpi.com/2077-0383/13/7/2091 |
| work_keys_str_mv | AT joycetinwingli effectofantiresorptivedrugsonosseointegrateddentalimplantsasystematicreview AT yiuyanleung effectofantiresorptivedrugsonosseointegrateddentalimplantsasystematicreview |