Zinc Supplementation Improves Nocturnal Asthma Symptoms
Background: Treatment of bronchial asthma aims to control the symptoms of bronchoconstriction and disease modification. Zinc influences bradykinin that promotes inflammation and promotes contraction of smooth muscle in the bronchus. Aim of the work: To test the effect of zinc supplementation on imp...
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| Format: | Article |
| Language: | English |
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Cairo University, Faculty of Medicine, Department of Pediatrics
2022-01-01
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| Series: | Pediatric Sciences Journal |
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| Online Access: | https://cupsj.journals.ekb.eg/article_210815_c2c35e97e199d3efbf7136a834eace48.pdf |
| _version_ | 1797790126895529984 |
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| author | Iman Abdelaziz Magd Ahmed Kotb Noha Adel Yassin Walaa Ahmed Rabie Alsayed Fathy Alsayed Dina Hossam Hamed |
| author_facet | Iman Abdelaziz Magd Ahmed Kotb Noha Adel Yassin Walaa Ahmed Rabie Alsayed Fathy Alsayed Dina Hossam Hamed |
| author_sort | Iman Abdelaziz |
| collection | DOAJ |
| description | Background: Treatment of bronchial asthma aims to control the symptoms of bronchoconstriction and disease modification. Zinc influences bradykinin that promotes inflammation and promotes contraction of smooth muscle in the bronchus.
Aim of the work: To test the effect of zinc supplementation on improvement of both clinical symptoms and lung functions in children with bronchial asthma.
Methods: Asthma symptoms, severity and pulmonary function tests were performed to 50 children with bronchial asthma before and after zinc supplementation (1mg/kg/ day) as adjuvant therapy. Serum zinc levels were assessed at initial enrollment for all 50 children.
Results: The studied cohort comprised 28 boys and 22 girls with age range of 6-13 years and mean age +/- SD of 8.88 +/- 2.24 years. Of them 48 %, 30 % and 22% were diagnosed: moderate persistent asthma, mild persistent and severe persistent asthma respectively. Initial serum zinc level was low in 34% of patients (mean 47.2 ±10.8 μg/dl) and 66% of patients had a normal initial serum zinc level (mean 100.6 ± 27.2 μg/dl). After 8 weeks of zinc supplementation there was a significant improvement in decreasing frequency of attacks (p=0.036), nocturnal symptoms (p˂ 0.001), clinical control of asthma symptoms (p˂ 0.001) and pulmonary functions showed significant improvement in forced expiratory volume in 1 second (FEV1) (p˂0.001) and forced vital capacity (FVC) (p=0.002) but there was no significant difference in the frequency of daytime symptoms (p˃0.05), limitation of activities (p˃0.05) or need for reliever medications (p˃0.05). Conclusion: Zinc is an effective adjuvant in controlling nocturnal symptoms and significantly improves pulmonary functions even if the initial serum zinc level was within the normal range. |
| first_indexed | 2024-03-13T02:00:19Z |
| format | Article |
| id | doaj.art-806008ea678b40a78f360e719397951a |
| institution | Directory Open Access Journal |
| issn | 2805-279X 2682-3985 |
| language | English |
| last_indexed | 2024-03-13T02:00:19Z |
| publishDate | 2022-01-01 |
| publisher | Cairo University, Faculty of Medicine, Department of Pediatrics |
| record_format | Article |
| series | Pediatric Sciences Journal |
| spelling | doaj.art-806008ea678b40a78f360e719397951a2023-07-02T03:52:53ZengCairo University, Faculty of Medicine, Department of PediatricsPediatric Sciences Journal2805-279X2682-39852022-01-0121101610.21608/CUPSJ.2021.107314.1038Zinc Supplementation Improves Nocturnal Asthma SymptomsIman Abdelaziz0https://orcid.org/0000-0001-5753-7181Magd Ahmed Kotb1https://orcid.org/0000-0003-2118-3793Noha Adel Yassin2https://orcid.org/0000-0002-9297-4990Walaa Ahmed Rabie3https://orcid.org/0000-0001-6197-3648Alsayed Fathy Alsayed4Dina Hossam Hamed5https://orcid.org/0000-0002-6927-5294Pediatrics Department, Faculty of Medicine, Cairo University, EgyptPediatrics Department, Faculty of Medicine, Cairo University, EgyptPediatrics Department, Faculty of Medicine, Cairo University, EgyptClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, EgyptPediatrics Department, Ashmoun Hospital, Menofeya, EgyptPediatrics Department, Faculty of Medicine, Cairo University, EgyptBackground: Treatment of bronchial asthma aims to control the symptoms of bronchoconstriction and disease modification. Zinc influences bradykinin that promotes inflammation and promotes contraction of smooth muscle in the bronchus. Aim of the work: To test the effect of zinc supplementation on improvement of both clinical symptoms and lung functions in children with bronchial asthma. Methods: Asthma symptoms, severity and pulmonary function tests were performed to 50 children with bronchial asthma before and after zinc supplementation (1mg/kg/ day) as adjuvant therapy. Serum zinc levels were assessed at initial enrollment for all 50 children. Results: The studied cohort comprised 28 boys and 22 girls with age range of 6-13 years and mean age +/- SD of 8.88 +/- 2.24 years. Of them 48 %, 30 % and 22% were diagnosed: moderate persistent asthma, mild persistent and severe persistent asthma respectively. Initial serum zinc level was low in 34% of patients (mean 47.2 ±10.8 μg/dl) and 66% of patients had a normal initial serum zinc level (mean 100.6 ± 27.2 μg/dl). After 8 weeks of zinc supplementation there was a significant improvement in decreasing frequency of attacks (p=0.036), nocturnal symptoms (p˂ 0.001), clinical control of asthma symptoms (p˂ 0.001) and pulmonary functions showed significant improvement in forced expiratory volume in 1 second (FEV1) (p˂0.001) and forced vital capacity (FVC) (p=0.002) but there was no significant difference in the frequency of daytime symptoms (p˃0.05), limitation of activities (p˃0.05) or need for reliever medications (p˃0.05). Conclusion: Zinc is an effective adjuvant in controlling nocturnal symptoms and significantly improves pulmonary functions even if the initial serum zinc level was within the normal range.https://cupsj.journals.ekb.eg/article_210815_c2c35e97e199d3efbf7136a834eace48.pdfbronchial asthmasymptomsnocturnal coughzinc sulfate |
| spellingShingle | Iman Abdelaziz Magd Ahmed Kotb Noha Adel Yassin Walaa Ahmed Rabie Alsayed Fathy Alsayed Dina Hossam Hamed Zinc Supplementation Improves Nocturnal Asthma Symptoms Pediatric Sciences Journal bronchial asthma symptoms nocturnal cough zinc sulfate |
| title | Zinc Supplementation Improves Nocturnal Asthma Symptoms |
| title_full | Zinc Supplementation Improves Nocturnal Asthma Symptoms |
| title_fullStr | Zinc Supplementation Improves Nocturnal Asthma Symptoms |
| title_full_unstemmed | Zinc Supplementation Improves Nocturnal Asthma Symptoms |
| title_short | Zinc Supplementation Improves Nocturnal Asthma Symptoms |
| title_sort | zinc supplementation improves nocturnal asthma symptoms |
| topic | bronchial asthma symptoms nocturnal cough zinc sulfate |
| url | https://cupsj.journals.ekb.eg/article_210815_c2c35e97e199d3efbf7136a834eace48.pdf |
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