<i>Gordonia hydrophobica</i> Nitrile Hydratase for Amide Preparation from Nitriles

<i>Gordonia hydrophobica</i> Nitrile Hydratase for Amide Preparation from Nitriles

The active pharmaceutical ingredient levetiracetam has anticonvulsant properties and is used to treat epilepsies. Herein, we describe the enantioselective preparation of the levetiracetam precursor 2-(pyrrolidine-1-yl)butanamide by enzymatic dynamic kinetic resolution with a nitrile hydratase enzyme...

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Bibliographic Details
Main Authors: Birgit Grill, Melissa Horvat, Helmut Schwab, Ralf Gross, Kai Donsbach, Margit Winkler
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Catalysts
Subjects:
small molecule
dynamic kinetic resolution
levetiracetam
nitrile hydratase
amino amide
amino nitrile
Online Access:https://www.mdpi.com/2073-4344/11/11/1287

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