Influencing factors of clinical efficacy of roxadustat among hemodialysis patients
AbstractObjective To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients.Methods Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography–tandem mass spectrom...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2308701 |
| _version_ | 1797316462957821952 |
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| author | Wenhui Wu Nan Hu Xiurong Li Jia Di Hua Zhou Hongyan Niu Min Yang |
| author_facet | Wenhui Wu Nan Hu Xiurong Li Jia Di Hua Zhou Hongyan Niu Min Yang |
| author_sort | Wenhui Wu |
| collection | DOAJ |
| description | AbstractObjective To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients.Methods Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS). A multiple logistic regression model was established to determine the factors that affect clinical efficacy of roxadustat in patients undergoing hemodialysis.Results A total of 67 hemodialysis patients were enrolled in the study. The results showed that age, blood trough concentration of roxadustat, and baseline hemoglobin (Hb) level were independent factors of clinical efficacy of roxadustat (OR = 1.06, p = .025 for age; OR = 1.001, p = .037 for plasma concentration; and OR = 0.941, p = .003 for baseline Hb), with an AUC score of 0.859.Conclusions Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients. |
| first_indexed | 2024-03-08T03:18:46Z |
| format | Article |
| id | doaj.art-806249233330466e840274b928e5d83b |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-08T03:18:46Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-806249233330466e840274b928e5d83b2024-02-12T11:14:08ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2308701Influencing factors of clinical efficacy of roxadustat among hemodialysis patientsWenhui Wu0Nan Hu1Xiurong Li2Jia Di3Hua Zhou4Hongyan Niu5Min Yang6Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaAbstractObjective To explore independent influencing factors for clinical efficacy of roxadustat in hemodialysis patients.Methods Hemodialysis patients treated with roxadustat were enrolled. The plasma trough concentrations of roxadustat were measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS). A multiple logistic regression model was established to determine the factors that affect clinical efficacy of roxadustat in patients undergoing hemodialysis.Results A total of 67 hemodialysis patients were enrolled in the study. The results showed that age, blood trough concentration of roxadustat, and baseline hemoglobin (Hb) level were independent factors of clinical efficacy of roxadustat (OR = 1.06, p = .025 for age; OR = 1.001, p = .037 for plasma concentration; and OR = 0.941, p = .003 for baseline Hb), with an AUC score of 0.859.Conclusions Age, blood trough concentration of roxadustat, and baseline Hb level were independent influencing factors of the response to roxadustat in hemodialysis patients.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2308701Roxadustatrenal anemiablood trough concentration of roxadustatclinical efficacy |
| spellingShingle | Wenhui Wu Nan Hu Xiurong Li Jia Di Hua Zhou Hongyan Niu Min Yang Influencing factors of clinical efficacy of roxadustat among hemodialysis patients Renal Failure Roxadustat renal anemia blood trough concentration of roxadustat clinical efficacy |
| title | Influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| title_full | Influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| title_fullStr | Influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| title_full_unstemmed | Influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| title_short | Influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| title_sort | influencing factors of clinical efficacy of roxadustat among hemodialysis patients |
| topic | Roxadustat renal anemia blood trough concentration of roxadustat clinical efficacy |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2308701 |
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