Bone strain index in the prediction of vertebral fragility refracture
Abstract Dual-energy x-ray absorptiometry (DXA) can provide quantitative (bone mineral density, BMD) and qualitative (trabecular bone score, TBS) indexes of bone status, able to predict fragility fractures in most osteoporotic patients. A new qualitative index of bone strength, based on finite eleme...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-04-01
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| Series: | European Radiology Experimental |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41747-020-00151-8 |
| _version_ | 1818319153044389888 |
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| author | Fabio Massimo Ulivieri Luca Petruccio Piodi Luca Rinaudo Paolo Scanagatta Bruno Mario Cesana |
| author_facet | Fabio Massimo Ulivieri Luca Petruccio Piodi Luca Rinaudo Paolo Scanagatta Bruno Mario Cesana |
| author_sort | Fabio Massimo Ulivieri |
| collection | DOAJ |
| description | Abstract Dual-energy x-ray absorptiometry (DXA) can provide quantitative (bone mineral density, BMD) and qualitative (trabecular bone score, TBS) indexes of bone status, able to predict fragility fractures in most osteoporotic patients. A new qualitative index of bone strength, based on finite element analysis and named bone strain index (BSI), has been recently developed from lumbar DXA scan. We present the preliminary results about the BSI ability to predict a refracture in patients with fragility fractures. A total of 143 consecutive fractured patients with primary osteoporosis (121 females) performed a spine x-ray examination for the calculation of spine deformity index (SDI) and a DXA densitometry for BMD, TBS, and BSI at basal time and in the follow-up. A refracture was considered as a one-unit increase in SDI. For each unit increase of the investigated indexes, the hazard ratio of refracture, 95% confidence interval, p value, and proportionality test p value were for BSI 1.201, 0.982−1.468, 0.074, and 0.218; for lumbar BMD 0.231, 0.028−1.877, 0.170, and 0.305; and for TBS 0.034, 0.001−2.579, 0.126, and 0.518, respectively. BSI was the index predictive of refracture nearest to statistical significance. If confirmed, it may be used for a better risk assessment of osteoporotic patients. |
| first_indexed | 2024-12-13T10:04:35Z |
| format | Article |
| id | doaj.art-80634f71b2a443efb15da3b3eac23eb0 |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-12-13T10:04:35Z |
| publishDate | 2020-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-80634f71b2a443efb15da3b3eac23eb02022-12-21T23:51:34ZengSpringerOpenEuropean Radiology Experimental2509-92802020-04-01411610.1186/s41747-020-00151-8Bone strain index in the prediction of vertebral fragility refractureFabio Massimo Ulivieri0Luca Petruccio Piodi1Luca Rinaudo2Paolo Scanagatta3Bruno Mario Cesana4Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, UO Medicina NucleareFormerly: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, UO Gastroenterologia ed Endoscopia DigestivaTECHNOLOGIC SrlScuola di Specializzazione in Medicina Fisica e Riabilitativa, Università degli Studi di MilanoUnità di Statistica Medica, Biometria e, Bioinformatica “Giulio A. Maccacaro”, Dipartimento di Scienze Cliniche e Salute della Comunità, Università degli Studi di MilanoAbstract Dual-energy x-ray absorptiometry (DXA) can provide quantitative (bone mineral density, BMD) and qualitative (trabecular bone score, TBS) indexes of bone status, able to predict fragility fractures in most osteoporotic patients. A new qualitative index of bone strength, based on finite element analysis and named bone strain index (BSI), has been recently developed from lumbar DXA scan. We present the preliminary results about the BSI ability to predict a refracture in patients with fragility fractures. A total of 143 consecutive fractured patients with primary osteoporosis (121 females) performed a spine x-ray examination for the calculation of spine deformity index (SDI) and a DXA densitometry for BMD, TBS, and BSI at basal time and in the follow-up. A refracture was considered as a one-unit increase in SDI. For each unit increase of the investigated indexes, the hazard ratio of refracture, 95% confidence interval, p value, and proportionality test p value were for BSI 1.201, 0.982−1.468, 0.074, and 0.218; for lumbar BMD 0.231, 0.028−1.877, 0.170, and 0.305; and for TBS 0.034, 0.001−2.579, 0.126, and 0.518, respectively. BSI was the index predictive of refracture nearest to statistical significance. If confirmed, it may be used for a better risk assessment of osteoporotic patients.http://link.springer.com/article/10.1186/s41747-020-00151-8Bone densityBone fracturesAbsorptiometry (dual-energy x-ray)Finite element analysisOsteoporosis |
| spellingShingle | Fabio Massimo Ulivieri Luca Petruccio Piodi Luca Rinaudo Paolo Scanagatta Bruno Mario Cesana Bone strain index in the prediction of vertebral fragility refracture European Radiology Experimental Bone density Bone fractures Absorptiometry (dual-energy x-ray) Finite element analysis Osteoporosis |
| title | Bone strain index in the prediction of vertebral fragility refracture |
| title_full | Bone strain index in the prediction of vertebral fragility refracture |
| title_fullStr | Bone strain index in the prediction of vertebral fragility refracture |
| title_full_unstemmed | Bone strain index in the prediction of vertebral fragility refracture |
| title_short | Bone strain index in the prediction of vertebral fragility refracture |
| title_sort | bone strain index in the prediction of vertebral fragility refracture |
| topic | Bone density Bone fractures Absorptiometry (dual-energy x-ray) Finite element analysis Osteoporosis |
| url | http://link.springer.com/article/10.1186/s41747-020-00151-8 |
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