Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody Escape

Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody Escape

High transmissibility is a hallmark of the Omicron variant of SARS-CoV-2. Understanding the molecular determinants of Omicron’s transmissibility will impact development of intervention strategies. Here we map the electrostatic potential surface of the Spike protein to show that major SARS-CoV-2 vari...

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Bibliographic Details
Main Authors: Hin Hark Gan, John Zinno, Fabio Piano, Kristin C. Gunsalus
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Virology
Subjects:
omicron variant
spike protein
electrostatic surface
antibody escape
ACE2 recognition
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2022.894531/full

Internet

https://www.frontiersin.org/articles/10.3389/fviro.2022.894531/full

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