Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course
Psoriasis is a persistent inflammatory skin disorder driven by T cells. The disease is characterized by aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins and arteries. The purpose of the study was to identify the levels of circulating lnc-HULC,...
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KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000252 |
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| author | Randa Erfan Olfat G. Shaker Mahmoud A.F. Khalil Aya M. AlOrbani Abeer K. Abu-El-Azayem Amira Samy Othman M. Zaki Haitham Abdelhamid Reham Fares Asmaa Mohammed |
| author_facet | Randa Erfan Olfat G. Shaker Mahmoud A.F. Khalil Aya M. AlOrbani Abeer K. Abu-El-Azayem Amira Samy Othman M. Zaki Haitham Abdelhamid Reham Fares Asmaa Mohammed |
| author_sort | Randa Erfan |
| collection | DOAJ |
| description | Psoriasis is a persistent inflammatory skin disorder driven by T cells. The disease is characterized by aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins and arteries. The purpose of the study was to identify the levels of circulating lnc-HULC, miR-122, and Sirtuin 1 (SIRT-1) in psoriatic patients, evaluate their possible roles as diagnostic biomarkers, and link their levels with the development of metabolic syndrome during psoriasis progression. This study included 176 participants. The subjects were divided into four groups, with 44 participants in each group. All patients have undergone a complete history taking and clinical examination. Laboratory investigations included Low-density lipoprotein (LDL), High-density lipoprotein (HDL), Triglycerides (TG), Fasting blood sugar (FBS), and cholesterol plasma levels. Serum levels of miR-122 and lnc-HULC were examined by qRT-PCR. Serum levels of SIRT-1 were examined by ELISA. The serum concentrations of lnc-HULC and miR-122 were significantly higher in psoriatic participants compared to controls. Psoriatic patients' serum concentrations of SIRT-1 were much lower than those of healthy individuals. There was a negative association between SIRT-1 concentration and BMI, disease duration, PASI score, LDL, and cholesterol levels. The blood levels of lnc-HULC, miR-122, and SIRT-1 in psoriasis patients provide a promising role as diagnostic biomarkers in patients with and without metabolic syndrome. |
| first_indexed | 2024-03-13T02:25:12Z |
| format | Article |
| id | doaj.art-8065a2e07b0242f48a77a5f015c6ec14 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-03-13T02:25:12Z |
| publishDate | 2023-09-01 |
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| series | Non-coding RNA Research |
| spelling | doaj.art-8065a2e07b0242f48a77a5f015c6ec142023-06-30T04:22:33ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-09-0183340349Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease courseRanda Erfan0Olfat G. Shaker1Mahmoud A.F. Khalil2Aya M. AlOrbani3Abeer K. Abu-El-Azayem4Amira Samy5Othman M. Zaki6Haitham Abdelhamid7Reham Fares8Asmaa Mohammed9Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, 12613, Egypt; Corresponding author.Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, 12613, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt; Corresponding author.Department of Dermatology, Faculty of Medicine, Cairo University, 12613, EgyptDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, 12613, Cairo, EgyptDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, 12613, Cairo, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Damietta University, Damietta, EgyptPlastic Surgery Center, Haar Restore Klinik, Cairo, 12613, EgyptDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, EgyptDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, EgyptPsoriasis is a persistent inflammatory skin disorder driven by T cells. The disease is characterized by aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins and arteries. The purpose of the study was to identify the levels of circulating lnc-HULC, miR-122, and Sirtuin 1 (SIRT-1) in psoriatic patients, evaluate their possible roles as diagnostic biomarkers, and link their levels with the development of metabolic syndrome during psoriasis progression. This study included 176 participants. The subjects were divided into four groups, with 44 participants in each group. All patients have undergone a complete history taking and clinical examination. Laboratory investigations included Low-density lipoprotein (LDL), High-density lipoprotein (HDL), Triglycerides (TG), Fasting blood sugar (FBS), and cholesterol plasma levels. Serum levels of miR-122 and lnc-HULC were examined by qRT-PCR. Serum levels of SIRT-1 were examined by ELISA. The serum concentrations of lnc-HULC and miR-122 were significantly higher in psoriatic participants compared to controls. Psoriatic patients' serum concentrations of SIRT-1 were much lower than those of healthy individuals. There was a negative association between SIRT-1 concentration and BMI, disease duration, PASI score, LDL, and cholesterol levels. The blood levels of lnc-HULC, miR-122, and SIRT-1 in psoriasis patients provide a promising role as diagnostic biomarkers in patients with and without metabolic syndrome.http://www.sciencedirect.com/science/article/pii/S2468054023000252PsoriasisMetabolic syndromeLnc-HULCMiR-122SIRT-1 |
| spellingShingle | Randa Erfan Olfat G. Shaker Mahmoud A.F. Khalil Aya M. AlOrbani Abeer K. Abu-El-Azayem Amira Samy Othman M. Zaki Haitham Abdelhamid Reham Fares Asmaa Mohammed Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course Non-coding RNA Research Psoriasis Metabolic syndrome Lnc-HULC MiR-122 SIRT-1 |
| title | Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| title_full | Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| title_fullStr | Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| title_full_unstemmed | Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| title_short | Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| title_sort | lnc hulc mir 122 and sirtulin 1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course |
| topic | Psoriasis Metabolic syndrome Lnc-HULC MiR-122 SIRT-1 |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000252 |
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