Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges
ABSTRACT Aims Low‐carbohydrate diets have become popular in the general community. The mutual relationship between the percentage of total energy intake from carbohydrates (CHO/E), glycemic control indices, and diabetes complications remains unclear. Materials and Methods This cross‐sectional study...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13999 |
| _version_ | 1797842648504991744 |
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| author | Keiko Osugi Yoshiki Kusunoki Mana Ohigashi Kenji Kusunoki Chikako Inoue Maki Inoue Ayako Takagi Taku Tsunoda Manabu Kadoya Kosuke Konishi Tomoyuki Katsuno Hidenori Koyama Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group |
| author_facet | Keiko Osugi Yoshiki Kusunoki Mana Ohigashi Kenji Kusunoki Chikako Inoue Maki Inoue Ayako Takagi Taku Tsunoda Manabu Kadoya Kosuke Konishi Tomoyuki Katsuno Hidenori Koyama Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group |
| author_sort | Keiko Osugi |
| collection | DOAJ |
| description | ABSTRACT Aims Low‐carbohydrate diets have become popular in the general community. The mutual relationship between the percentage of total energy intake from carbohydrates (CHO/E), glycemic control indices, and diabetes complications remains unclear. Materials and Methods This cross‐sectional study included 177 patients with type 2 diabetes mellitus who regularly visited outpatient clinics. In this study, dietary questionnaires were used to assess the intake ratio of the three macronutrients, and the low‐carbohydrate‐diet score was calculated. We investigated the association between the low‐carbohydrate‐diet score, continuous glucose monitoring (CGM)‐derived short‐term glycemic control indices, and diabetes complications in patients with type 2 diabetes mellitus. Results The results are presented as medians (interquartile ranges) unless otherwise stated. Hemoglobin A1c was 7.1% (6.6–7.7%), CGM‐derived time in range (TIR) was 75.3% (62.8–87.0%), body mass index (BMI) was 24.0 (22.1–26.3) kg/m2, and CHO/E was 49.8% (44.8–55.6%). BMI, triglycerides, and CGM‐derived time above range decreased significantly with increasing low‐carbohydrate‐diet scores. However, no significant association was found between the low‐carbohydrate‐diet score and glycemic control indices, including TIR, mean amplitude of glycemic excursions, and vascular complications of type 2 diabetes mellitus. Conclusion Moderate‐carbohydrate diets positively impact weight control and lipid metabolism but may have a limited effect on short‐term glycemic variability in Japanese patients with type 2 diabetes mellitus. |
| first_indexed | 2024-04-09T16:51:19Z |
| format | Article |
| id | doaj.art-806652f002f54ef6b9918efdae550095 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-09T16:51:19Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-806652f002f54ef6b9918efdae5500952023-04-21T10:37:28ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-05-0114565966810.1111/jdi.13999Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in rangesKeiko Osugi0Yoshiki Kusunoki1Mana Ohigashi2Kenji Kusunoki3Chikako Inoue4Maki Inoue5Ayako Takagi6Taku Tsunoda7Manabu Kadoya8Kosuke Konishi9Tomoyuki Katsuno10Hidenori Koyama11Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study groupDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanKusunoki Clinic Neyagawa, Osaka JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Occupational Therapy, School of Rehabilitation Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine Hyogo Medical University Nishinomiya Hyogo JapanABSTRACT Aims Low‐carbohydrate diets have become popular in the general community. The mutual relationship between the percentage of total energy intake from carbohydrates (CHO/E), glycemic control indices, and diabetes complications remains unclear. Materials and Methods This cross‐sectional study included 177 patients with type 2 diabetes mellitus who regularly visited outpatient clinics. In this study, dietary questionnaires were used to assess the intake ratio of the three macronutrients, and the low‐carbohydrate‐diet score was calculated. We investigated the association between the low‐carbohydrate‐diet score, continuous glucose monitoring (CGM)‐derived short‐term glycemic control indices, and diabetes complications in patients with type 2 diabetes mellitus. Results The results are presented as medians (interquartile ranges) unless otherwise stated. Hemoglobin A1c was 7.1% (6.6–7.7%), CGM‐derived time in range (TIR) was 75.3% (62.8–87.0%), body mass index (BMI) was 24.0 (22.1–26.3) kg/m2, and CHO/E was 49.8% (44.8–55.6%). BMI, triglycerides, and CGM‐derived time above range decreased significantly with increasing low‐carbohydrate‐diet scores. However, no significant association was found between the low‐carbohydrate‐diet score and glycemic control indices, including TIR, mean amplitude of glycemic excursions, and vascular complications of type 2 diabetes mellitus. Conclusion Moderate‐carbohydrate diets positively impact weight control and lipid metabolism but may have a limited effect on short‐term glycemic variability in Japanese patients with type 2 diabetes mellitus.https://doi.org/10.1111/jdi.13999Continuous glucose monitoringLow‐carbohydrate dietTime in range |
| spellingShingle | Keiko Osugi Yoshiki Kusunoki Mana Ohigashi Kenji Kusunoki Chikako Inoue Maki Inoue Ayako Takagi Taku Tsunoda Manabu Kadoya Kosuke Konishi Tomoyuki Katsuno Hidenori Koyama Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges Journal of Diabetes Investigation Continuous glucose monitoring Low‐carbohydrate diet Time in range |
| title | Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges |
| title_full | Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges |
| title_fullStr | Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges |
| title_full_unstemmed | Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges |
| title_short | Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges |
| title_sort | association between low carbohydrate diets and continuous glucose monitoring derived time in ranges |
| topic | Continuous glucose monitoring Low‐carbohydrate diet Time in range |
| url | https://doi.org/10.1111/jdi.13999 |
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