PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery
Due to the specific physiological pH throughout the human body, pH-responsive polymers have been considered for aiding drug delivery systems. Depending on the surrounding pH conditions, the polymers can undergo swelling or contraction behaviors, and a degradation mechanism can release incorporated s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/9/1672 |
| _version_ | 1797503256038998016 |
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| author | Rachel Yie Hang Tan Choy Sin Lee Mallikarjuna Rao Pichika Sit Foon Cheng Ki Yan Lam |
| author_facet | Rachel Yie Hang Tan Choy Sin Lee Mallikarjuna Rao Pichika Sit Foon Cheng Ki Yan Lam |
| author_sort | Rachel Yie Hang Tan |
| collection | DOAJ |
| description | Due to the specific physiological pH throughout the human body, pH-responsive polymers have been considered for aiding drug delivery systems. Depending on the surrounding pH conditions, the polymers can undergo swelling or contraction behaviors, and a degradation mechanism can release incorporated substances. Additionally, polyurethane, a highly versatile polymer, has been reported for its biocompatibility properties, in which it demonstrates good biological response and sustainability in biomedical applications. In this review, we focus on summarizing the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years. In recent studies, there have been great developments in pH-responsive polyurethanes used as controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Other applications such as surface biomaterials, sensors, and optical imaging probes are also discussed in this review. |
| first_indexed | 2024-03-10T03:47:57Z |
| format | Article |
| id | doaj.art-80665a0314ab49468041b40c70270341 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T03:47:57Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-80665a0314ab49468041b40c702703412023-11-23T09:04:36ZengMDPI AGPolymers2073-43602022-04-01149167210.3390/polym14091672PH Responsive Polyurethane for the Advancement of Biomedical and Drug DeliveryRachel Yie Hang Tan0Choy Sin Lee1Mallikarjuna Rao Pichika2Sit Foon Cheng3Ki Yan Lam4School of Postgraduate, International Medical University, Kuala Lumpur 57000, MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur 57000, MalaysiaDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Kuala Lumpur 57000, MalaysiaUnit of Research on Lipids (URL), Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaSchool of Postgraduate, International Medical University, Kuala Lumpur 57000, MalaysiaDue to the specific physiological pH throughout the human body, pH-responsive polymers have been considered for aiding drug delivery systems. Depending on the surrounding pH conditions, the polymers can undergo swelling or contraction behaviors, and a degradation mechanism can release incorporated substances. Additionally, polyurethane, a highly versatile polymer, has been reported for its biocompatibility properties, in which it demonstrates good biological response and sustainability in biomedical applications. In this review, we focus on summarizing the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years. In recent studies, there have been great developments in pH-responsive polyurethanes used as controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Other applications such as surface biomaterials, sensors, and optical imaging probes are also discussed in this review.https://www.mdpi.com/2073-4360/14/9/1672pH-responsivepolyurethanebiomedicaldrug delivery |
| spellingShingle | Rachel Yie Hang Tan Choy Sin Lee Mallikarjuna Rao Pichika Sit Foon Cheng Ki Yan Lam PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery Polymers pH-responsive polyurethane biomedical drug delivery |
| title | PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery |
| title_full | PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery |
| title_fullStr | PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery |
| title_full_unstemmed | PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery |
| title_short | PH Responsive Polyurethane for the Advancement of Biomedical and Drug Delivery |
| title_sort | ph responsive polyurethane for the advancement of biomedical and drug delivery |
| topic | pH-responsive polyurethane biomedical drug delivery |
| url | https://www.mdpi.com/2073-4360/14/9/1672 |
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