Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety
<p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-05-01
|
| Series: | Patient Safety in Surgery |
| Online Access: | http://www.pssjournal.com/content/2/1/13 |
| _version_ | 1811260492281282560 |
|---|---|
| author | Papadimos Thomas J Grum Daniel F Fahed Samir |
| author_facet | Papadimos Thomas J Grum Daniel F Fahed Samir |
| author_sort | Papadimos Thomas J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.</p> |
| first_indexed | 2024-04-12T18:48:07Z |
| format | Article |
| id | doaj.art-8066e2e7b3ba4b7f91ead4caaa00b1ce |
| institution | Directory Open Access Journal |
| issn | 1754-9493 |
| language | English |
| last_indexed | 2024-04-12T18:48:07Z |
| publishDate | 2008-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Patient Safety in Surgery |
| spelling | doaj.art-8066e2e7b3ba4b7f91ead4caaa00b1ce2022-12-22T03:20:33ZengBMCPatient Safety in Surgery1754-94932008-05-01211310.1186/1754-9493-2-13Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safetyPapadimos Thomas JGrum Daniel FFahed Samir<p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.</p>http://www.pssjournal.com/content/2/1/13 |
| spellingShingle | Papadimos Thomas J Grum Daniel F Fahed Samir Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety Patient Safety in Surgery |
| title | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
| title_full | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
| title_fullStr | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
| title_full_unstemmed | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
| title_short | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
| title_sort | labetalol infusion for refractory hypertension causing severe hypotension and bradycardia an issue of patient safety |
| url | http://www.pssjournal.com/content/2/1/13 |
| work_keys_str_mv | AT papadimosthomasj labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety AT grumdanielf labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety AT fahedsamir labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety |