Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety
<p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2008-05-01
|
Series: | Patient Safety in Surgery |
Online Access: | http://www.pssjournal.com/content/2/1/13 |
_version_ | 1811260492281282560 |
---|---|
author | Papadimos Thomas J Grum Daniel F Fahed Samir |
author_facet | Papadimos Thomas J Grum Daniel F Fahed Samir |
author_sort | Papadimos Thomas J |
collection | DOAJ |
description | <p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.</p> |
first_indexed | 2024-04-12T18:48:07Z |
format | Article |
id | doaj.art-8066e2e7b3ba4b7f91ead4caaa00b1ce |
institution | Directory Open Access Journal |
issn | 1754-9493 |
language | English |
last_indexed | 2024-04-12T18:48:07Z |
publishDate | 2008-05-01 |
publisher | BMC |
record_format | Article |
series | Patient Safety in Surgery |
spelling | doaj.art-8066e2e7b3ba4b7f91ead4caaa00b1ce2022-12-22T03:20:33ZengBMCPatient Safety in Surgery1754-94932008-05-01211310.1186/1754-9493-2-13Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safetyPapadimos Thomas JGrum Daniel FFahed Samir<p>Abstract</p> <p>Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.</p>http://www.pssjournal.com/content/2/1/13 |
spellingShingle | Papadimos Thomas J Grum Daniel F Fahed Samir Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety Patient Safety in Surgery |
title | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
title_full | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
title_fullStr | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
title_full_unstemmed | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
title_short | Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety |
title_sort | labetalol infusion for refractory hypertension causing severe hypotension and bradycardia an issue of patient safety |
url | http://www.pssjournal.com/content/2/1/13 |
work_keys_str_mv | AT papadimosthomasj labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety AT grumdanielf labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety AT fahedsamir labetalolinfusionforrefractoryhypertensioncausingseverehypotensionandbradycardiaanissueofpatientsafety |