Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection
Some individuals can spontaneously clear the hepatitis C virus (HCV) after infection, whereas others develop a chronic infection. The exact mechanism of this phenomenon is unknown. We aimed to evaluate the association of plasma levels of MBL, L-ficolin, and cytokines with outcome of HCV infections i...
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.587669/full |
| _version_ | 1818522019258433536 |
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| author | Jing Zhang Ning Chen Zhiyun Chen Yali Liu Kai Zheng Yundong Qiu Nan Zhang Junping Zhu Haibin Yu Qiushui He Qiushui He |
| author_facet | Jing Zhang Ning Chen Zhiyun Chen Yali Liu Kai Zheng Yundong Qiu Nan Zhang Junping Zhu Haibin Yu Qiushui He Qiushui He |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Some individuals can spontaneously clear the hepatitis C virus (HCV) after infection, whereas others develop a chronic infection. The exact mechanism of this phenomenon is unknown. We aimed to evaluate the association of plasma levels of MBL, L-ficolin, and cytokines with outcome of HCV infections in two groups of patients who cleared HCV spontaneously (CHS), and who developed chronic HCV infections (CHC). Altogether, 86 patients and 183 healthy controls were included. Of 86 patients, 36 had CHS and 50 had CHC. Concentrations of plasma MBL and L-ficolin were measured in patients and controls. Twenty plasma cytokines and adhesion molecules, including GM-CSF, ICAM-1, IFN-γ, IFN-α, IL-1α, IL-1β, IL-10, IL-12p70, IL-13, IL-17A, IL-4, IL-8, IP-10, MCP-1, IL-6, MIP-1α, MIP-1β, sE-Selectin, sP-Selectin, and TNF-α, were determined in all patients and randomly selected 45 controls. The level of MBL was significantly lower in subjects with CHS than in healthy controls (median: 293.10 vs. 482.64 ng/ml, p = 0.008), whereas the level of MBL was significantly higher in patients with CHC than in controls (median: 681.32 vs. 482.64 ng/ml, p = 0.001). No such differences in plasma L-ficolin were observed. Plasma levels of all cytokines and adhesion molecules, except ICAM-1, were significantly higher in patients than in controls. Moreover, patients with CHC had significantly higher levels of IFN-γ, IFN-α, IL-1α, IL-10, IL-13, IL-4, IL-6, and TNF-α than those with CHS. These findings implicate that lower levels of plasma MBL, together with lower levels of above mentioned cytokines may play a part in virus clearance of HCV infection. |
| first_indexed | 2024-12-11T03:59:02Z |
| format | Article |
| id | doaj.art-806722bf84b244d899a4b1e0c77d0137 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T03:59:02Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-806722bf84b244d899a4b1e0c77d01372022-12-22T01:21:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.587669587669Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After InfectionJing Zhang0Ning Chen1Zhiyun Chen2Yali Liu3Kai Zheng4Yundong Qiu5Nan Zhang6Junping Zhu7Haibin Yu8Qiushui He9Qiushui He10The Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaDepartment of Traditional Chinese Medicine, Gu’an Hospital of Traditional Chinese Medicine, Gu’an, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaThe Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, Capital Medical University, Beijing, ChinaDepartment of Medical Microbiology, University of Turku, Turku, FinlandSome individuals can spontaneously clear the hepatitis C virus (HCV) after infection, whereas others develop a chronic infection. The exact mechanism of this phenomenon is unknown. We aimed to evaluate the association of plasma levels of MBL, L-ficolin, and cytokines with outcome of HCV infections in two groups of patients who cleared HCV spontaneously (CHS), and who developed chronic HCV infections (CHC). Altogether, 86 patients and 183 healthy controls were included. Of 86 patients, 36 had CHS and 50 had CHC. Concentrations of plasma MBL and L-ficolin were measured in patients and controls. Twenty plasma cytokines and adhesion molecules, including GM-CSF, ICAM-1, IFN-γ, IFN-α, IL-1α, IL-1β, IL-10, IL-12p70, IL-13, IL-17A, IL-4, IL-8, IP-10, MCP-1, IL-6, MIP-1α, MIP-1β, sE-Selectin, sP-Selectin, and TNF-α, were determined in all patients and randomly selected 45 controls. The level of MBL was significantly lower in subjects with CHS than in healthy controls (median: 293.10 vs. 482.64 ng/ml, p = 0.008), whereas the level of MBL was significantly higher in patients with CHC than in controls (median: 681.32 vs. 482.64 ng/ml, p = 0.001). No such differences in plasma L-ficolin were observed. Plasma levels of all cytokines and adhesion molecules, except ICAM-1, were significantly higher in patients than in controls. Moreover, patients with CHC had significantly higher levels of IFN-γ, IFN-α, IL-1α, IL-10, IL-13, IL-4, IL-6, and TNF-α than those with CHS. These findings implicate that lower levels of plasma MBL, together with lower levels of above mentioned cytokines may play a part in virus clearance of HCV infection.https://www.frontiersin.org/articles/10.3389/fimmu.2020.587669/fullhepatitis C virusspontaneous clearancemannose-binding lectinL-ficolincytokine profilegenotyping |
| spellingShingle | Jing Zhang Ning Chen Zhiyun Chen Yali Liu Kai Zheng Yundong Qiu Nan Zhang Junping Zhu Haibin Yu Qiushui He Qiushui He Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection Frontiers in Immunology hepatitis C virus spontaneous clearance mannose-binding lectin L-ficolin cytokine profile genotyping |
| title | Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection |
| title_full | Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection |
| title_fullStr | Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection |
| title_full_unstemmed | Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection |
| title_short | Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection |
| title_sort | low mannose binding lectin but not l ficolin is associated with spontaneous clearance of hepatitis c virus after infection |
| topic | hepatitis C virus spontaneous clearance mannose-binding lectin L-ficolin cytokine profile genotyping |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.587669/full |
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