Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly

Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly

The linear ubiquitin chain assembly complex (LUBAC) is the sole identified E3 ligase complex that catalyzes the formation of linear ubiquitin chain, and it is composed of HOIP, HOIL-1L, and SHARPIN. The E3 activity of HOIP can be effectively activated by HOIL-1L or SHARPIN, deficiency of which leads...

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Bibliographic Details
Main Authors: Jianping Liu, Yingli Wang, Yukang Gong, Tao Fu, Shichen Hu, Zixuan Zhou, Lifeng Pan
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
SHARPIN
HOIP
HOIL-1L
LUBAC
linear ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313062

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