Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer
ContextThyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs.ObjectiveTo evaluate th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.769074/full |
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| author | Jun Choul Lee Byong-Sop Song Young Mi Kang Yu-Ri Kim Yea Eun Kang Ju Hee Lee Minho Shong Hyon-Seung Yi Hyon-Seung Yi |
| author_facet | Jun Choul Lee Byong-Sop Song Young Mi Kang Yu-Ri Kim Yea Eun Kang Ju Hee Lee Minho Shong Hyon-Seung Yi Hyon-Seung Yi |
| author_sort | Jun Choul Lee |
| collection | DOAJ |
| description | ContextThyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs.ObjectiveTo evaluate the relationships of TSH concentration with muscle mass, muscle strength, and physical performance related to sarcopenia in patients with DTC undergoing TSH suppression following surgery.MethodsWe studied 134 patients of >60 years who were undergoing TSH suppression therapy following surgery for DTC. We evaluated muscle mass and muscle function-related parameters and diagnosed sarcopenia using the threshold for Asian people.ResultsThe participants were 68.3 ± 7.2 years old and 36/134 (26.9%) were diagnosed with sarcopenia. They were allocated to high-TSH and low-TSH groups using a threshold concentration of 0.40 μU/mL, and grip strength was significantly lower in the low-TSH group. The data were further analyzed according to age and sex, and in the low-TSH group, male participants and those of <70 years were found to have significantly lower grip strength.ConclusionsLow-TSH concentrations is associated with low grip strength, and this is most pronounced in individuals of <70 years of age. Therefore, muscle function should be considered an adverse effect of TSH suppression in patients with DTC who undergo TSH suppression therapy, especially in men of <70 years. |
| first_indexed | 2024-12-19T00:00:14Z |
| format | Article |
| id | doaj.art-80698afb2c64492b8fe62e2938a506dd |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-19T00:00:14Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-80698afb2c64492b8fe62e2938a506dd2022-12-21T20:46:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-11-011210.3389/fendo.2021.769074769074Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid CancerJun Choul Lee0Byong-Sop Song1Young Mi Kang2Yu-Ri Kim3Yea Eun Kang4Ju Hee Lee5Minho Shong6Hyon-Seung Yi7Hyon-Seung Yi8Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaDepartment of Core Laboratory of Translational Research, Biomedical Convergence Research Center, Chungnam National University Hospital, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South KoreaDepartment of Core Laboratory of Translational Research, Biomedical Convergence Research Center, Chungnam National University Hospital, Daejeon, South KoreaContextThyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs.ObjectiveTo evaluate the relationships of TSH concentration with muscle mass, muscle strength, and physical performance related to sarcopenia in patients with DTC undergoing TSH suppression following surgery.MethodsWe studied 134 patients of >60 years who were undergoing TSH suppression therapy following surgery for DTC. We evaluated muscle mass and muscle function-related parameters and diagnosed sarcopenia using the threshold for Asian people.ResultsThe participants were 68.3 ± 7.2 years old and 36/134 (26.9%) were diagnosed with sarcopenia. They were allocated to high-TSH and low-TSH groups using a threshold concentration of 0.40 μU/mL, and grip strength was significantly lower in the low-TSH group. The data were further analyzed according to age and sex, and in the low-TSH group, male participants and those of <70 years were found to have significantly lower grip strength.ConclusionsLow-TSH concentrations is associated with low grip strength, and this is most pronounced in individuals of <70 years of age. Therefore, muscle function should be considered an adverse effect of TSH suppression in patients with DTC who undergo TSH suppression therapy, especially in men of <70 years.https://www.frontiersin.org/articles/10.3389/fendo.2021.769074/fullthyroid-stimulating hormonesarcopeniathyroidectomythyroid cancermuscle function and physical activity |
| spellingShingle | Jun Choul Lee Byong-Sop Song Young Mi Kang Yu-Ri Kim Yea Eun Kang Ju Hee Lee Minho Shong Hyon-Seung Yi Hyon-Seung Yi Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer Frontiers in Endocrinology thyroid-stimulating hormone sarcopenia thyroidectomy thyroid cancer muscle function and physical activity |
| title | Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer |
| title_full | Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer |
| title_fullStr | Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer |
| title_full_unstemmed | Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer |
| title_short | Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer |
| title_sort | effect of thyroid stimulating hormone suppression on muscle function after total thyroidectomy in patients with thyroid cancer |
| topic | thyroid-stimulating hormone sarcopenia thyroidectomy thyroid cancer muscle function and physical activity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.769074/full |
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