Antibody Therapies for Large B-Cell Lymphoma
Mattia Novo,1 Elisa Santambrogio,2 Pio Manlio Mirko Frascione,3,4 Delia Rota-Scalabrini,1 Umberto Vitolo1 1Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy; 2Hematology Unit, Santa Croce e Carle Hospital, Cuneo, Italy; 3Medical Oncology, Candiolo Canc...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-05-01
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| Series: | Biologics: Targets & Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/antibody-therapies-for-large-b-cell-lymphoma-peer-reviewed-fulltext-article-BTT |
| _version_ | 1819195811571957760 |
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| author | Novo M Santambrogio E Frascione PMM Rota-Scalabrini D Vitolo U |
| author_facet | Novo M Santambrogio E Frascione PMM Rota-Scalabrini D Vitolo U |
| author_sort | Novo M |
| collection | DOAJ |
| description | Mattia Novo,1 Elisa Santambrogio,2 Pio Manlio Mirko Frascione,3,4 Delia Rota-Scalabrini,1 Umberto Vitolo1 1Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy; 2Hematology Unit, Santa Croce e Carle Hospital, Cuneo, Italy; 3Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy; 4Department of Oncology, University of Turin, Torino, ItalyCorrespondence: Mattia NovoMultidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142 km 3.95, Candiolo, 10060, ItalyTel +39 011-993-3250Fax +39 011-9333275Email mattia.novo@ircc.itAbstract: Large B-cell lymphomas (LBCLs) constitute a subgroup of aggressive but highly curable lymphoproliferative diseases. Treatment of relapsed/refractory (R/R) patients still represents an unmet clinical need, and novel drugs and combinations are in continuous development. The pan–B cell panel of surface antigens that characterizes LBCL leads to a large umbrella of druggable targets. Monoclonal antibodies (mAbs) express their activity against lymphoma by targeting multiple tumor-specific antigens. This category consists of a number of molecules with different mechanisms of action, including naked mAbs, radioimmunoconjugates, antibody-drug conjugates, checkpoint inhibitors, and bispecific antibodies. In the last decade, apart from the well-known role of the anti-CD20 mAb rituximab, novel mAbs have led to remarkable steps forward in the treatment of R/R LBCL in monotherapy and combined with chemotherapy. Multiple studies are in development trying to bring these novel compounds into the frontline setting to empower the RCHOP effect or as alternative chemotherapy-free options for elderly/unfit patients. This review provides insight into antilymphoma mAbs, focused on the efficacy and safety of the main molecules approved or in development for LBCL andperspectives on the treatment of this disease.Keywords: diffuse large B-cell lymphoma, immunotherapy, targeted therapy, monoclonal antibodies, checkpoint inhibitors, bispecific antibodies |
| first_indexed | 2024-12-23T02:18:41Z |
| format | Article |
| id | doaj.art-80698fcb410343ee8a3f82861413072a |
| institution | Directory Open Access Journal |
| issn | 1177-5491 |
| language | English |
| last_indexed | 2024-12-23T02:18:41Z |
| publishDate | 2021-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-80698fcb410343ee8a3f82861413072a2022-12-21T18:03:36ZengDove Medical PressBiologics: Targets & Therapy1177-54912021-05-01Volume 1515317464875Antibody Therapies for Large B-Cell LymphomaNovo MSantambrogio EFrascione PMMRota-Scalabrini DVitolo UMattia Novo,1 Elisa Santambrogio,2 Pio Manlio Mirko Frascione,3,4 Delia Rota-Scalabrini,1 Umberto Vitolo1 1Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy; 2Hematology Unit, Santa Croce e Carle Hospital, Cuneo, Italy; 3Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy; 4Department of Oncology, University of Turin, Torino, ItalyCorrespondence: Mattia NovoMultidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142 km 3.95, Candiolo, 10060, ItalyTel +39 011-993-3250Fax +39 011-9333275Email mattia.novo@ircc.itAbstract: Large B-cell lymphomas (LBCLs) constitute a subgroup of aggressive but highly curable lymphoproliferative diseases. Treatment of relapsed/refractory (R/R) patients still represents an unmet clinical need, and novel drugs and combinations are in continuous development. The pan–B cell panel of surface antigens that characterizes LBCL leads to a large umbrella of druggable targets. Monoclonal antibodies (mAbs) express their activity against lymphoma by targeting multiple tumor-specific antigens. This category consists of a number of molecules with different mechanisms of action, including naked mAbs, radioimmunoconjugates, antibody-drug conjugates, checkpoint inhibitors, and bispecific antibodies. In the last decade, apart from the well-known role of the anti-CD20 mAb rituximab, novel mAbs have led to remarkable steps forward in the treatment of R/R LBCL in monotherapy and combined with chemotherapy. Multiple studies are in development trying to bring these novel compounds into the frontline setting to empower the RCHOP effect or as alternative chemotherapy-free options for elderly/unfit patients. This review provides insight into antilymphoma mAbs, focused on the efficacy and safety of the main molecules approved or in development for LBCL andperspectives on the treatment of this disease.Keywords: diffuse large B-cell lymphoma, immunotherapy, targeted therapy, monoclonal antibodies, checkpoint inhibitors, bispecific antibodieshttps://www.dovepress.com/antibody-therapies-for-large-b-cell-lymphoma-peer-reviewed-fulltext-article-BTTdiffuse large b cell lymphomaimmunotherapytarget therapymonoclonal antibodiescheckpoint inhibitorsbispecific antibodies. |
| spellingShingle | Novo M Santambrogio E Frascione PMM Rota-Scalabrini D Vitolo U Antibody Therapies for Large B-Cell Lymphoma Biologics: Targets & Therapy diffuse large b cell lymphoma immunotherapy target therapy monoclonal antibodies checkpoint inhibitors bispecific antibodies. |
| title | Antibody Therapies for Large B-Cell Lymphoma |
| title_full | Antibody Therapies for Large B-Cell Lymphoma |
| title_fullStr | Antibody Therapies for Large B-Cell Lymphoma |
| title_full_unstemmed | Antibody Therapies for Large B-Cell Lymphoma |
| title_short | Antibody Therapies for Large B-Cell Lymphoma |
| title_sort | antibody therapies for large b cell lymphoma |
| topic | diffuse large b cell lymphoma immunotherapy target therapy monoclonal antibodies checkpoint inhibitors bispecific antibodies. |
| url | https://www.dovepress.com/antibody-therapies-for-large-b-cell-lymphoma-peer-reviewed-fulltext-article-BTT |
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