A convenient protocol for establishing a human cell culture model of the outer retina. [version 1; referees: 2 approved]
The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are reported in Age-related Macular Degeneration, Stargardt and Best disease as well as pattern dystrophies. However, the precise role of RPE cells i...
Main Authors: | Savannah A. Lynn, Eloise Keeling, Jennifer M. Dewing, David A. Johnston, Anton Page, Angela J. Cree, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka |
---|---|
Format: | Article |
Language: | English |
Published: |
F1000 Research Ltd
2018-07-01
|
Series: | F1000Research |
Online Access: | https://f1000research.com/articles/7-1107/v1 |
Similar Items
-
3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina
by: Eloise Keeling, et al.
Published: (2020-11-01) -
Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases
by: Eloise Keeling, et al.
Published: (2018-02-01) -
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy
by: Eloise Keeling, et al.
Published: (2020-09-01) -
The complexities underlying age-related macular degeneration: could amyloid beta play an important role?
by: Savannah A Lynn, et al.
Published: (2017-01-01) -
Oligomeric Aβ<sub>1-42</sub> Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
by: Savannah A. Lynn, et al.
Published: (2021-02-01)