Therapeutic Implications of microRNAs in Depressive Disorders: A Review
MicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/21/13530 |
| _version_ | 1797467857456463872 |
|---|---|
| author | Mubashir Hassan Aqsa Amir Saba Shahzadi Andrzej Kloczkowski |
| author_facet | Mubashir Hassan Aqsa Amir Saba Shahzadi Andrzej Kloczkowski |
| author_sort | Mubashir Hassan |
| collection | DOAJ |
| description | MicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that interfere with a person’s everyday activities. In this review, we have focused on exploration of the significant role of miRNAs in depression by affecting associated target proteins (cellular and synaptic) and their signaling pathways which can be controlled by the attachment of miRNAs at transcriptional and translational levels. Moreover, miRNAs have potential role as biomarkers and may help to cure depression through involvement and interactions with multiple pharmacological and physiological therapies. Taken together, miRNAs might be considered as promising novel therapy targets themselves and may interfere with currently available antidepressant treatments. |
| first_indexed | 2024-03-09T18:59:41Z |
| format | Article |
| id | doaj.art-806ad6a683aa4fe285c3829b1a4c39b5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:59:41Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-806ad6a683aa4fe285c3829b1a4c39b52023-11-24T05:09:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211353010.3390/ijms232113530Therapeutic Implications of microRNAs in Depressive Disorders: A ReviewMubashir Hassan0Aqsa Amir1Saba Shahzadi2Andrzej Kloczkowski3The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAInstitute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore 54590, PakistanThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children Hospital, Columbus, OH 43205, USAMicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that interfere with a person’s everyday activities. In this review, we have focused on exploration of the significant role of miRNAs in depression by affecting associated target proteins (cellular and synaptic) and their signaling pathways which can be controlled by the attachment of miRNAs at transcriptional and translational levels. Moreover, miRNAs have potential role as biomarkers and may help to cure depression through involvement and interactions with multiple pharmacological and physiological therapies. Taken together, miRNAs might be considered as promising novel therapy targets themselves and may interfere with currently available antidepressant treatments.https://www.mdpi.com/1422-0067/23/21/13530depressionMicroRNAdepressive disorderanxiety |
| spellingShingle | Mubashir Hassan Aqsa Amir Saba Shahzadi Andrzej Kloczkowski Therapeutic Implications of microRNAs in Depressive Disorders: A Review International Journal of Molecular Sciences depression MicroRNA depressive disorder anxiety |
| title | Therapeutic Implications of microRNAs in Depressive Disorders: A Review |
| title_full | Therapeutic Implications of microRNAs in Depressive Disorders: A Review |
| title_fullStr | Therapeutic Implications of microRNAs in Depressive Disorders: A Review |
| title_full_unstemmed | Therapeutic Implications of microRNAs in Depressive Disorders: A Review |
| title_short | Therapeutic Implications of microRNAs in Depressive Disorders: A Review |
| title_sort | therapeutic implications of micrornas in depressive disorders a review |
| topic | depression MicroRNA depressive disorder anxiety |
| url | https://www.mdpi.com/1422-0067/23/21/13530 |
| work_keys_str_mv | AT mubashirhassan therapeuticimplicationsofmicrornasindepressivedisordersareview AT aqsaamir therapeuticimplicationsofmicrornasindepressivedisordersareview AT sabashahzadi therapeuticimplicationsofmicrornasindepressivedisordersareview AT andrzejkloczkowski therapeuticimplicationsofmicrornasindepressivedisordersareview |