Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis
Atherosclerosis is the formation of plaque within arteries due to overt assemblage of fats, cholesterol and fibrous material causing a blockage of the free flow of blood leading to ischemia. It is harshly impinging on health statistics worldwide because of being principal cause of high morbidity and...
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MDPI AG
2023-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/2/261 |
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| author | Puneetpal Singh Nitin Kumar Monica Singh Manminder Kaur Gurjinderpal Singh Amit Narang Abhinav Kanwal Kirti Sharma Baani Singh Mario Di Napoli Sarabjit Mastana |
| author_facet | Puneetpal Singh Nitin Kumar Monica Singh Manminder Kaur Gurjinderpal Singh Amit Narang Abhinav Kanwal Kirti Sharma Baani Singh Mario Di Napoli Sarabjit Mastana |
| author_sort | Puneetpal Singh |
| collection | DOAJ |
| description | Atherosclerosis is the formation of plaque within arteries due to overt assemblage of fats, cholesterol and fibrous material causing a blockage of the free flow of blood leading to ischemia. It is harshly impinging on health statistics worldwide because of being principal cause of high morbidity and mortality for several diseases including rheumatological, heart and brain disorders. Atherosclerosis is perpetuated by pro-inflammatory and exacerbated by pro-coagulatory mediators. Besides several other pathways, the formation of neutrophil extracellular traps (NETs) and the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contribute significantly to the initiation and propagation of atherosclerotic plaque for its worst outcomes. The present review highlights the contribution of these two disturbing processes in atherosclerosis, inflammation and atherothrombosis in their individual as well as collaborative manner. |
| first_indexed | 2024-03-11T08:02:57Z |
| format | Article |
| id | doaj.art-806c656b5da847b9bf41ce0d8e9b44b8 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T08:02:57Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-806c656b5da847b9bf41ce0d8e9b44b82023-11-16T23:41:58ZengMDPI AGVaccines2076-393X2023-01-0111226110.3390/vaccines11020261Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and AtherothrombosisPuneetpal Singh0Nitin Kumar1Monica Singh2Manminder Kaur3Gurjinderpal Singh4Amit Narang5Abhinav Kanwal6Kirti Sharma7Baani Singh8Mario Di Napoli9Sarabjit Mastana10Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, IndiaDivision of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, IndiaDivision of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, IndiaDepartment of Neurology, MK Neuro Centre, Patiala 147002, IndiaDepartment of Neurology, Bhatia Hospital Neuro and Multispecialty, Patiala 147002, IndiaDepartment of Neurosurgery, All India Institute of Medical Sciences (AIIMS), Bathinda 151005, IndiaDepartment of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bathinda 151005, IndiaDivision of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, IndiaDivision of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, IndiaDepartment of Neurological Service, Annunziata Hospital, Sulmona, 67039 L’Aquila, ItalyHuman Genomics Laboratory, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UKAtherosclerosis is the formation of plaque within arteries due to overt assemblage of fats, cholesterol and fibrous material causing a blockage of the free flow of blood leading to ischemia. It is harshly impinging on health statistics worldwide because of being principal cause of high morbidity and mortality for several diseases including rheumatological, heart and brain disorders. Atherosclerosis is perpetuated by pro-inflammatory and exacerbated by pro-coagulatory mediators. Besides several other pathways, the formation of neutrophil extracellular traps (NETs) and the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contribute significantly to the initiation and propagation of atherosclerotic plaque for its worst outcomes. The present review highlights the contribution of these two disturbing processes in atherosclerosis, inflammation and atherothrombosis in their individual as well as collaborative manner.https://www.mdpi.com/2076-393X/11/2/261atherosclerosisinflammationatherothrombosisneutrophilsmonocytesmacrophages |
| spellingShingle | Puneetpal Singh Nitin Kumar Monica Singh Manminder Kaur Gurjinderpal Singh Amit Narang Abhinav Kanwal Kirti Sharma Baani Singh Mario Di Napoli Sarabjit Mastana Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis Vaccines atherosclerosis inflammation atherothrombosis neutrophils monocytes macrophages |
| title | Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis |
| title_full | Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis |
| title_fullStr | Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis |
| title_full_unstemmed | Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis |
| title_short | Neutrophil Extracellular Traps and NLRP3 Inflammasome: A Disturbing Duo in Atherosclerosis, Inflammation and Atherothrombosis |
| title_sort | neutrophil extracellular traps and nlrp3 inflammasome a disturbing duo in atherosclerosis inflammation and atherothrombosis |
| topic | atherosclerosis inflammation atherothrombosis neutrophils monocytes macrophages |
| url | https://www.mdpi.com/2076-393X/11/2/261 |
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