The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A<sub>3</sub> Receptor Agonist, in a Rat Model of Colitis

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A<sub>3</sub> Receptor Agonist, in a Rat Model of Colitis

The pharmacological activation of A<sub>3</sub> receptors has shown potential usefulness in the management of bowel inflammation. However, the role of these receptors in the control of visceral hypersensitivity in the presence of intestinal inflammation has not been investigated. The eff...

Full description

Bibliographic Details
Main Authors:	Luca Antonioli, Elena Lucarini, Catia Lambertucci, Matteo Fornai, Carolina Pellegrini, Laura Benvenuti, Lorenzo Di Cesare Mannelli, Andrea Spinaci, Gabriella Marucci, Corrado Blandizzi, Carla Ghelardini, Rosaria Volpini, Diego Dal Ben
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Cells
Subjects:	A<sub>3</sub> adenosine receptors immune cells experimental colitis DNBS visceral pain oxidative stress
Online Access:	https://www.mdpi.com/2073-4409/9/6/1509

Similar Items

A<sub>3</sub> Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity
by: Andrea Spinaci, et al.
Published: (2022-01-01)

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors, and Efficacy in Animal Models of Depression
by: Flavia Varano, et al.
Published: (2021-07-01)

Adenosine Receptors as Neuroinflammation Modulators: Role of A<sub>1</sub> Agonists and A<sub>2A</sub> Antagonists
by: Aleix Martí Navia, et al.
Published: (2020-07-01)

Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A<sub>1</sub> Receptor Ligands
by: Mariachiara Zuccarini, et al.
Published: (2021-12-01)

A<sub>2A</sub> Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?
by: Andrea Spinaci, et al.
Published: (2022-04-01)

How Are Adenosine and Adenosine A<sub>2A</sub> Receptors Involved in the Pathophysiology of Amyotrophic Lateral Sclerosis?
by: Akihisa Mori, et al.
Published: (2021-08-01)

Combined Therapy of A<sub>1</sub>AR Agonists and A<sub>2A</sub>AR Antagonists in Neuroinflammation
by: Gabriella Marucci, et al.
Published: (2021-02-01)

The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia
by: Vanessa D’Antongiovanni, et al.
Published: (2020-07-01)

Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A<sub>2A</sub> Adenosine Receptor Useful in Neurodegenerative Disorders
by: Beatrice Francucci, et al.
Published: (2023-06-01)

Managing Obesity and Related Comorbidities: A Potential Pharmacological Target in the Adenosine System?
by: Vanessa D’Antongiovanni, et al.
Published: (2021-01-01)

Glial A<sub>2B</sub> Adenosine Receptors Modulate Abnormal Tachykininergic Responses and Prevent Enteric Inflammation Associated with High Fat Diet-Induced Obesity
by: Vanessa D’Antongiovanni, et al.
Published: (2020-05-01)

Adenosine A<sub>2A</sub> Receptors Shut Down Adenosine A<sub>1</sub> Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation
by: Cátia R. Lopes, et al.
Published: (2023-04-01)

“Dual Anta-Inhibitors” of the A<sub>2A</sub> Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
by: Andrea Spinaci, et al.
Published: (2023-01-01)

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A<sub>1</sub> Receptor
by: Jeroen Spanoghe, et al.
Published: (2020-12-01)

Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A<sub>3</sub> Receptor Subtype
by: Elisabetta Coppi, et al.
Published: (2021-07-01)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A<sub>2B</sub> Receptor Binding Affinity
by: Marcel Lindemann, et al.
Published: (2021-05-01)

Adenosine A<sub>3</sub> Receptor (A<sub>3</sub>AR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice
by: Silvia Sgambellone, et al.
Published: (2022-11-01)

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview
by: Diego Dal Ben, et al.
Published: (2019-10-01)

Development of a Radiofluorinated Adenosine A<sub>2B</sub> Receptor Antagonist as Potential Ligand for PET Imaging
by: Marcel Lindemann, et al.
Published: (2020-04-01)

Characterization and Seasonal Modulation of Adenosine A<sub>1</sub> Receptors in the Arctic Ground Squirrel Brain
by: Zachary Carlson, et al.
Published: (2023-01-01)

The Histamine H<sub>4</sub> Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A<sub>3</sub> Receptor Agonist IB-MECA: Role of CD4<sup>+</sup> T Cells
by: Laura Micheli, et al.
Published: (2021-10-01)

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors
by: Monica Frinchi, et al.
Published: (2020-12-01)

Inflammatory Bowel Diseases: It's Time for the Adenosine System
by: Luca Antonioli, et al.
Published: (2020-07-01)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A<sub>2A</sub> and A<sub>2B</sub> Receptor Antagonists Determined in Rat Blood
by: Monika Kubacka, et al.
Published: (2023-08-01)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A<sub>2A</sub> and Dual A<sub>1</sub>/A<sub>2A</sub> Receptor Affinity
by: Michał Załuski, et al.
Published: (2023-09-01)

Expression and Impact of Adenosine A<sub>3</sub> Receptors on Calcium Homeostasis in Human Right Atrium
by: Carmen Tarifa, et al.
Published: (2023-02-01)

Pomegranate Mesocarp against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions
by: Carmen Parisio, et al.
Published: (2020-06-01)

Hypoxia Depresses Synaptic Transmission in the Primary Motor Cortex of the Infant Rat—Role of Adenosine A<sub>1</sub> Receptors and Nitric Oxide
by: Isabella Zironi, et al.
Published: (2022-11-01)

Pharmacology of Adenosine Receptors: Recent Advancements
by: Fabrizio Vincenzi, et al.
Published: (2023-09-01)

Adenosine Receptors Profile in Fibromuscular Dysplasia
by: Claire Guiol, et al.
Published: (2022-11-01)

A<sub>2A</sub> Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer’s Disease
by: Stefania Gessi, et al.
Published: (2021-09-01)

Functional Expression of Adenosine A<sub>3</sub> Receptor in Yeast Utilizing a Chimera with the A<sub>2A</sub>R C-Terminus
by: Abhinav R. Jain, et al.
Published: (2020-06-01)

Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease
by: Cátia R. Lopes, et al.
Published: (2023-07-01)

Curcumin Stereoisomer, Cis-Trans Curcumin, as a Novel Ligand to A<sub>1</sub> and A<sub>3</sub> Adenosine Receptors
by: Luke J. Hamilton, et al.
Published: (2023-06-01)

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A<sub>2B</sub> Adenosine Receptor
by: Ángelo Torres, et al.
Published: (2020-04-01)

Activation of Adenosine A<sub>3</sub> Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure
by: Joana Ferreira-Silva, et al.
Published: (2020-09-01)

The Adenosine A<sub>2B</sub> Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments
by: Helen J. Knowles
Published: (2019-06-01)

Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation
by: Luca Antonioli, et al.
Published: (2021-06-01)

Adenosine Receptor Agonists Exhibit Anti-Platelet Effects and the Potential to Overcome Resistance to P2Y<sub>12</sub> Receptor Antagonists
by: Nina Wolska, et al.
Published: (2019-12-01)

Allosteric Antagonism of the A<sub>2A</sub> Adenosine Receptor by a Series of Bitopic Ligands
by: Zhan-Guo Gao, et al.
Published: (2020-05-01)