The Role of FNDC5/Irisin in Cardiovascular Disease
Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury. In myocardial infarction, cardiomyocyte metabolism is regulated by mitochondrial changes and biogenesis, which allows energy homeos...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/3/277 |
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| author | Maciej Grzeszczuk Piotr Dzięgiel Katarzyna Nowińska |
| author_facet | Maciej Grzeszczuk Piotr Dzięgiel Katarzyna Nowińska |
| author_sort | Maciej Grzeszczuk |
| collection | DOAJ |
| description | Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury. In myocardial infarction, cardiomyocyte metabolism is regulated by mitochondrial changes and biogenesis, which allows energy homeostasis. There are many proteins in cells that regulate and control metabolic processes. One of them is irisin (Ir), which is released from the transmembrane protein FNDC5. Initial studies indicated that Ir is a myokine secreted mainly by skeletal muscles. Further studies showed that Ir was also present in various tissues. However, its highest levels were observed in cardiomyocytes. Ir is responsible for many processes, including the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) by increasing the expression of thermogenin (UCP1). In addition, Ir affects mitochondrial biogenesis. Therefore, the levels of FNDC5/Ir in the blood and myocardium may be important in cardiovascular disease. This review discusses the current knowledge about the role of FNDC5/Ir in cardiovascular disease. |
| first_indexed | 2024-03-08T03:59:42Z |
| format | Article |
| id | doaj.art-80748fa5e5074ac29e06c614511a91c7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T03:59:42Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-80748fa5e5074ac29e06c614511a91c72024-02-09T15:09:51ZengMDPI AGCells2073-44092024-02-0113327710.3390/cells13030277The Role of FNDC5/Irisin in Cardiovascular DiseaseMaciej Grzeszczuk0Piotr Dzięgiel1Katarzyna Nowińska2Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, PolandDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, PolandDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, PolandDisorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury. In myocardial infarction, cardiomyocyte metabolism is regulated by mitochondrial changes and biogenesis, which allows energy homeostasis. There are many proteins in cells that regulate and control metabolic processes. One of them is irisin (Ir), which is released from the transmembrane protein FNDC5. Initial studies indicated that Ir is a myokine secreted mainly by skeletal muscles. Further studies showed that Ir was also present in various tissues. However, its highest levels were observed in cardiomyocytes. Ir is responsible for many processes, including the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) by increasing the expression of thermogenin (UCP1). In addition, Ir affects mitochondrial biogenesis. Therefore, the levels of FNDC5/Ir in the blood and myocardium may be important in cardiovascular disease. This review discusses the current knowledge about the role of FNDC5/Ir in cardiovascular disease.https://www.mdpi.com/2073-4409/13/3/277irisinfibronectin type III domain-containing protein 5<i>FNDC5</i>myocardial infarction |
| spellingShingle | Maciej Grzeszczuk Piotr Dzięgiel Katarzyna Nowińska The Role of FNDC5/Irisin in Cardiovascular Disease Cells irisin fibronectin type III domain-containing protein 5 <i>FNDC5</i> myocardial infarction |
| title | The Role of FNDC5/Irisin in Cardiovascular Disease |
| title_full | The Role of FNDC5/Irisin in Cardiovascular Disease |
| title_fullStr | The Role of FNDC5/Irisin in Cardiovascular Disease |
| title_full_unstemmed | The Role of FNDC5/Irisin in Cardiovascular Disease |
| title_short | The Role of FNDC5/Irisin in Cardiovascular Disease |
| title_sort | role of fndc5 irisin in cardiovascular disease |
| topic | irisin fibronectin type III domain-containing protein 5 <i>FNDC5</i> myocardial infarction |
| url | https://www.mdpi.com/2073-4409/13/3/277 |
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