Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models

Inhibition of serum- and glucocorticoid-induced kinase 1 ameliorates hydrocephalus in preclinical models

Abstract Background Hydrocephalus is a pathological accumulation of cerebrospinal fluid (CSF), leading to ventriculomegaly. Hydrocephalus may be primary or secondary to traumatic brain injury, infection, or intracranial hemorrhage. Regardless of cause, current treatment involves surgery to drain the...

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Main Authors: Alexandra Hochstetler, Hillary Smith, Makenna Reed, Louise Hulme, Paul Territo, Amanda Bedwell, Scott Persohn, Nicola Perrotti, Lucia D’Antona, Francesca Musumeci, Silvia Schenone, Bonnie L. Blazer-Yost
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Hydrocephalus
Choroid plexus
Transepithelial epithelial ion transport
Serum- and glucocorticoid-induced kinase 1
Online Access:https://doi.org/10.1186/s12987-023-00461-0

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