The Dual Role of Chemerin in Lung Diseases
Chemerin is an atypical chemokine first described as a chemoattractant agent for monocytes, natural killer cells, plasmacytoid and myeloid dendritic cells, through interaction with its main receptor, the G protein-coupled receptor chemokine-like receptor 1 (CMKLR1). Chemerin has been studied in vari...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/2/171 |
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| author | Philomène Lavis Benjamin Bondue Alessandra Kupper Cardozo |
| author_facet | Philomène Lavis Benjamin Bondue Alessandra Kupper Cardozo |
| author_sort | Philomène Lavis |
| collection | DOAJ |
| description | Chemerin is an atypical chemokine first described as a chemoattractant agent for monocytes, natural killer cells, plasmacytoid and myeloid dendritic cells, through interaction with its main receptor, the G protein-coupled receptor chemokine-like receptor 1 (CMKLR1). Chemerin has been studied in various lung disease models, showing both pro- and anti-inflammatory properties. Given the incidence and burden of inflammatory lung diseases from diverse origins (infectious, autoimmune, age-related, etc.), chemerin has emerged as an interesting therapeutical target due to its immunomodulatory role. However, as highlighted by this review, further research efforts to elucidate the mechanisms governing chemerin’s dual pro- and anti-inflammatory characteristics are urgently needed. Moreover, although a growing body of evidence suggests chemerin as a potential biomarker for the diagnosis and/or prognosis of inflammatory lung diseases, this review underscores the necessity for standardizing both sampling types and measurement techniques before drawing definitive conclusions. |
| first_indexed | 2024-03-08T09:55:54Z |
| format | Article |
| id | doaj.art-8075edbb0a9b40a2ac610f526b418c21 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T09:55:54Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8075edbb0a9b40a2ac610f526b418c212024-01-29T13:50:32ZengMDPI AGCells2073-44092024-01-0113217110.3390/cells13020171The Dual Role of Chemerin in Lung DiseasesPhilomène Lavis0Benjamin Bondue1Alessandra Kupper Cardozo2Department of Pathology, Brussels University Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumInstitut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (I.R.I.B.H.M.), Université Libre de Bruxelles, 1070 Brussels, BelgiumInflammation and Cell Death Signalling Group, Signal Transduction and Metabolism Laboratory, Université Libre de Bruxelles, 1070 Brussels, BelgiumChemerin is an atypical chemokine first described as a chemoattractant agent for monocytes, natural killer cells, plasmacytoid and myeloid dendritic cells, through interaction with its main receptor, the G protein-coupled receptor chemokine-like receptor 1 (CMKLR1). Chemerin has been studied in various lung disease models, showing both pro- and anti-inflammatory properties. Given the incidence and burden of inflammatory lung diseases from diverse origins (infectious, autoimmune, age-related, etc.), chemerin has emerged as an interesting therapeutical target due to its immunomodulatory role. However, as highlighted by this review, further research efforts to elucidate the mechanisms governing chemerin’s dual pro- and anti-inflammatory characteristics are urgently needed. Moreover, although a growing body of evidence suggests chemerin as a potential biomarker for the diagnosis and/or prognosis of inflammatory lung diseases, this review underscores the necessity for standardizing both sampling types and measurement techniques before drawing definitive conclusions.https://www.mdpi.com/2073-4409/13/2/171chemerinRARRES2CMKLR1lunginflammation |
| spellingShingle | Philomène Lavis Benjamin Bondue Alessandra Kupper Cardozo The Dual Role of Chemerin in Lung Diseases Cells chemerin RARRES2 CMKLR1 lung inflammation |
| title | The Dual Role of Chemerin in Lung Diseases |
| title_full | The Dual Role of Chemerin in Lung Diseases |
| title_fullStr | The Dual Role of Chemerin in Lung Diseases |
| title_full_unstemmed | The Dual Role of Chemerin in Lung Diseases |
| title_short | The Dual Role of Chemerin in Lung Diseases |
| title_sort | dual role of chemerin in lung diseases |
| topic | chemerin RARRES2 CMKLR1 lung inflammation |
| url | https://www.mdpi.com/2073-4409/13/2/171 |
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